Flexible Docking of Squamous Cell Carcinoma Antigen 2and Cathepsin-G

Abstract

Abstract: The most softwares for protein-protein docking are regarded as two proteins being rigid, and take no account of the flexibility of proteins, which causes conformation variety of the interface because of interaction of the interface amino acids.On the premise of the rigidity of protein-protein docking, by the method of molecular dynamic simulation, we search the protein-protein interface conformations of the complexes which grounded on the rigid docking.Since the interaction of the amino acid was taken into account, to a certain extent, the complex conformations are more perfect.

Key words: Docking, Flexibility, Dynamic simulation, FTDOCK

CLC Number:

O641

TrendMD:

GAO Xue-Feng, HUANG Xu-Ri, SUN Yan-Bo . Flexible Docking of Squamous Cell Carcinoma Antigen 2and Cathepsin-G[J]. Chem. J. Chinese Universities, 2003, 24(10): 1883.

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Flexible Docking of Squamous Cell Carcinoma Antigen 2and Cathepsin-G

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