Chem. J. Chinese Universities ›› 2021, Vol. 42 ›› Issue (10): 3099.doi: 10.7503/cjcu20200897

• Organic Chemistry • Previous Articles     Next Articles

Host-guest Complexation Behavior of Nardosinone and Water-soluble Phosphate Salt Pillar[6]arene

YANG Ju, SU Lijiao, LI Canhua, LU Jiajia, YANG Junli, GU Jie, YANG Li(), YANG Lijuan()   

  1. Key Laboratory of Intelligent Supramolecular Chemistry at the University of Yunnan Province,National and Local Joint Engineering Research Center for Green Preparation Technology of Biobased Materials,School of Chemistry & Environment,Yunnan Minzu University,Kunming 650500,China
  • Received:2021-05-15 Online:2021-10-10 Published:2021-10-10
  • Contact: YANG Li,YANG Lijuan


Using water-soluble phosphate salt pillar[6]arene(WP6P) as the host and the natural drug nardosinone(ND) as the guest, the saturated solution method was used to construct a new the host-guest inclusion compound of ND/WP6P. The complexation behavior between the host and guest was studied by UV spectrome- tric titration. The results showed that ND and WP6P formed inclusion compound at a molar ratio of 1∶1, and the complex constant was 5.160×104 L/mol. Infrared spectroscopy(IR), X-ray powder diffraction(XRD), thermos gravimetry(TG), differential thermal analysis(DSC) and scanning electron microscope(SEM) were used to characterize the ND/WP6P inclusion compound. The possible inclusion mode of between ND and WP6P was further verified by nuclear magnetic resonance(1H NMR, 2D NMR) and molecular docking simulation. This study provides a theoretical reference for the application of water-soluble pillar[6]arene in natural medicine.

Key words: Water-soluble phosphate saltpillar[6]arene, Nardosinone, Inclusion complex, Molecular docking

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