Studies on Synthesis and Antitumor Activities of Analogues and Segments of Papaver Somniferum Pollen Heptadecapeptide

Abstract

Abstract: Four analogues and three segments were designed and synthesized by using solidphase peptide synthesis method according to separated papaver somniferum pollen heptade-capeptide with promoting immunity and antitumor activities as the leading compound.Theirprimary secondary structures in solution were determined by CDspectra and their inhibitiveactivities to human gastric and bladder cancer cells were assayed by MTTmethod.The rela-tionship of structure-activity was preliminarily discussed.

Key words: Papaver somniferum pollen, Pollen peptide, Antitumor activity, Analogue, Segment

CLC Number:

O629.11.7

TrendMD:

XU Jia-Xi, JIN Sheng. Studies on Synthesis and Antitumor Activities of Analogues and Segments of Papaver Somniferum Pollen Heptadecapeptide[J]. Chem. J. Chinese Universities, 1997, 18(7): 1098.

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Studies on Synthesis and Antitumor Activities of Analogues and Segments of Papaver Somniferum Pollen Heptadecapeptide

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