Studies on the Structure of Metal Serum Albumin(Ⅷ)──A Fluorescence EXAFS Study of the Zinc Ion Centers of Zn(Ⅱ)-HSA and Zn(Ⅱ)-BSA Complexes

Chem. J. Chinese Universities ›› 1997, Vol. 18 ›› Issue (6): 851.

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Studies on the Structure of Metal Serum Albumin(Ⅷ)──A Fluorescence EXAFS Study of the Zinc Ion Centers of Zn(Ⅱ)-HSA and Zn(Ⅱ)-BSA Complexes

Zhou Yong-Qia¹, ZHANG Xi-Quan¹, HE Jin-Tian¹, LIANG Xian-Zhen¹, OU YANG Di¹, HU Tian-Dou², XIE Ya-Ning²

1. Department of Chemistry, Nankai University, Tianjin, 300071;
2. Beijing Electron Position Collider National Laboratory, Beijing, 100039

Received:1996-05-06 Online:1997-06-24 Published:1997-06-24

Abstract

Abstract: It has been proved that in the Zn(Ⅱ)-HSAand Zn(Ⅱ)-BSAcomplexes, the in-ternuclear distance between Zn(Ⅱ) and its nearest binding atoms is 0.201 nm and 0.203 nm, the coordinate number is about four, the coordinate atoms are probably nitrogen atoms, and the possibility of sulfur of cysteine binding to Zn(Ⅱ) is basically excluded. The results are consequently discussed.

Key words: Fluorescence EXAFS, Human serum albumin, Bovine serum albumin, Zinc ion center

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Zhou Yong-Qia, ZHANG Xi-Quan, HE Jin-Tian, LIANG Xian-Zhen, OU YANG Di, HU Tian-Dou, XIE Ya-Ning. Studies on the Structure of Metal Serum Albumin(Ⅷ)──A Fluorescence EXAFS Study of the Zinc Ion Centers of Zn(Ⅱ)-HSA and Zn(Ⅱ)-BSA Complexes[J]. Chem. J. Chinese Universities, 1997, 18(6): 851.

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Studies on the Structure of Metal Serum Albumin(Ⅷ)──A Fluorescence EXAFS Study of the Zinc Ion Centers of Zn(Ⅱ)-HSA and Zn(Ⅱ)-BSA Complexes

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