Synthesis of(N-p-Tolueneslfonyl)α-aminobenzylphjosphonic Acid and Its Monoesters and Their Biological Activities

Chem. J. Chinese Universities ›› 1997, Vol. 18 ›› Issue (12): 1992.

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Synthesis of(N-p-Tolueneslfonyl)α-aminobenzylphjosphonic Acid and Its Monoesters and Their Biological Activities

DAI Qing, CHEN Ru-Yu

Institute of Elemento-Orga,lic Chemistry, Nankai University, Tianjin 300071

Received:1996-10-28 Online:1997-12-24 Published:1997-12-24

Abstract

Abstract: The titIe compounds were synthesized by the Mannich-type reactions involving p-toluenesulfonamide, various aromatic aldehydes and alkoxydichlorophosphine (phosphorus-trichloride) in acetyl chloride and subsequent hydrolysis.The reaction mechanism was sug-gested according to the results of ³¹P NMRtracing reactions- The bioassays showed thatsome of the products possess potential anti-TMVactivity.

Key words: α-Aminophosphonic acid, Mannich-type reaction, reaction mechanism, TMV

CLC Number:

O626.23

TrendMD:

DAI Qing, CHEN Ru-Yu. Synthesis of(N-p-Tolueneslfonyl)α-aminobenzylphjosphonic Acid and Its Monoesters and Their Biological Activities[J]. Chem. J. Chinese Universities, 1997, 18(12): 1992.

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Synthesis of(N-p-Tolueneslfonyl)α-aminobenzylphjosphonic Acid and Its Monoesters and Their Biological Activities

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