Chem. J. Chinese Universities ›› 1996, Vol. 17 ›› Issue (3): 429.

• Articles • Previous Articles     Next Articles

Synthesis of 5'-O-(N,N-Bis(2-chloroethyl) phosphoramide)-2',3',-O-isopropylidenenucleosides

CHEN Ru-Yu, CHI Guo-Chen, CHEN Xiao-Ru   

  1. Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071
  • Received:1995-03-19 Online:1996-03-24 Published:1996-03-24

Abstract: Anumber of new title compounds were synthesized.The structures of all the products had been confirmed by elementary analysis,1H NMRand IR.The results of preliminary biological tests indicated that the title compounds had the inhibition effect against HL-60 cell lines and BCap cell lines.

Key words: Nucleoside, Phosphitylate, Antitumor activity

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