Synthesis and Antitumor Activity of Amino Acid 5-Fluorouracil-1,3-dipropyl Esters Hydrochloride

Abstract

Abstract: Ten amino acid 5-fluorouracil-1,3-dipropyl esters hydrochloride were obtained by the reaction of N-protected salts of amino acid with 1,3-bis(w-bromopropyl)-5-fluorouracil in the DMF and then deprotecting with HCl-MeOH. The structures of these new compounds were characterized by ¹H NMR, IR and UV spectra as well as elemental analysis. The antitumor activities of all of the compounds were tested against EAC in vitro, the preliminary results showed that some of the compounds exhibit certain anititumor activity.

Key words: Antitumor agent, Aminoacid, 5-Fluorouracil, 5-Fluorouracil, Amino acid, Antitumor activity

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Zhao Rulin, Fan Changlie, Zhuo Renxi . Synthesis and Antitumor Activity of Amino Acid 5-Fluorouracil-1,3-dipropyl Esters Hydrochloride[J]. Chem. J. Chinese Universities, 1990, 11(5): 543.

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Synthesis and Antitumor Activity of Amino Acid 5-Fluorouracil-1,3-dipropyl Esters Hydrochloride

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