Synthesis of Amino Acid 5-Fluorouracil Esters Derivatives and Study on Their Antitumor Activity

Abstract

Abstract: Eighteen amino acid 5-fluoroiu-acil-propyl(butyl) ester hydrochlorides were synthesized by the reaction of N-protected salts of amino acids with 1-(w-bromopropyl)-5-fluorouracil and 1-(w-bromobutyl)-5-fluorouracil in DMF. The structures of these new compounds were characterized by ¹H NMR, IRand UVspectra, as well as elemental analysis, Tyrosine and phenylalanine 5-fluorouracil-propyl ester hydrochlorides show an inhibition ratio of 88.1% and 86.7% respectively against Ehrlich Ascites Carcinoma in mice.

Key words: Antitumor agent, Aminoacid, 5-Fluorouracil, 5-Fluorouracil, Amino acid, Antitumor activity

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Zhao Rulin, Fan Changlie, Zhuo Renxi . Synthesis of Amino Acid 5-Fluorouracil Esters Derivatives and Study on Their Antitumor Activity[J]. Chem. J. Chinese Universities, 1989, 10(6): 605.

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Synthesis of Amino Acid 5-Fluorouracil Esters Derivatives and Study on Their Antitumor Activity

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