Influences of Modifiers and Methods of Modification on Activity and Antigenicity of 1-Asparaginase

Abstract

Abstract: Small and macromolecular modifiers and different methods were used for modification of E. coli L-asparaginase to reduce the antigenicity.The results showed that the macromolecular modifiers are better than that of small molecular modifier acetic anhydride for reduction of antigenicity.Acomparison of the modified L-asparaginase by PEG, dextran,dextran sulfate and heparin showed that there is a relationship between the rate of modified free amino groups and the reduction of antigenicity.

Key words: L-asparaginase, PEG, Acetic anhydride, Chemical modification

TrendMD:

Cao Shugui, Tian Jie, Wang Ni, Cheng Yuhua . Influences of Modifiers and Methods of Modification on Activity and Antigenicity of 1-Asparaginase[J]. Chem. J. Chinese Universities, 1989, 10(3): 289.

References

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