Preparation of Magnetic Drug Carriers with Evodiamine and Fe3O4 Nanoparticles Co-encapsulated

doi:10.7503/cjcu20130807

Abstract

Abstract:

Evodiamine and Fe₃O₄ nanoparticles were co-encapsulated by dialysis method with methoxy poly(ethylene glycol)/poly(lactide-co-glycolide)(mPEG-PLGA) as carriers. The magnetic drug carriers were characterized through transmission electron microscope(TEM), Fourier transform infrared spectrum(FTIR), UV-Vis spectrum(UV), in vitro release action, Prussian blue staining, in vitro cytotoxicity and magnetic targeting study. The data suggested that Fe₃O₄ nanoparticles and drug loaded micelles were spherical morphology with narrow size distribution, and had high entrapment capacity with slow release in vitro release profiles. Furthermore, the Fe₃O₄ nanoparticles and drug loaded micelles were safe and had magnetic targeting properties.

Key words: Magnetic nanoparticle, Poly(ethylene glycol)/poly(lactide-co-glycolide)(mPEG-PLGA), Evodiamine, Sustained-release, Magnetic targeting property

CLC Number:

O631

TrendMD:

WANG Yan, WANG Xiao-Ying, LV Yan-Yun, XU Wen-Bin, GUO Yi, XU Li. Preparation of Magnetic Drug Carriers with Evodiamine and Fe₃O₄ Nanoparticles Co-encapsulated[J]. Chem. J. Chinese Universities, 2013, 34(12): 2866.

References

[1] Liao C. H., Pan S. L., Guh J. H., Chang Y. L., Pai H. C., Lin C. H., Teng C. M., Carcinogenesis, 2005, 26, 968—975

[2] Yang Z. G., Chen A. Q., Liu B., Cancer Biother., 2009, 6, 924—933

[3] Sutton D., Nasongkla N., Blanco E., Gao J. M., J. Pharm. Res., 2007, 24, 1029—1046

[4] Pablico-Lansigan M. H., Hickling W. J., Japp E. A., Rodriguez O. C., Ghosh A., Albanese C., Nishida M., Keuren E. V., Fricke S., Dollahon N., Stoll S. L., ACS Nano, 2013, 7(10), 9040-9048

[5] Ding G. B., Liu H. Y., Wang Y., Lv Y. Y., Wu Y., Guo Y., Xu L., Chem. Res. Chinese Universities, 2012, 28(1), 41—46

[6] Lv Y. Y., Ding G. B., Zhai J. H., Guo Y., Nie G. J., Xu L., J. Colloids Surf. B Biointerfaces, 2013, 110, 411—418

[7] Haag R., Chem. Int. Ed., 2004, 43(3), 278—282

[8] Shuai X. T., Merdan T., Schaper A. K., Xi F., Kissel T., Bioconjugate Chem., 2004, 15(3), 441—448

[9] Fujioka T., Taketani S., Nagasaki T., Matsumoto A., Bioconjugate Chem., 2009, 20, 1879—1887

[10] Thierry B., Zimmer L., McNiven S., Finnie K., Barbé C., Griesser H. J., Langmuir, 2008, 24, 8143—8150

[11] Reddy L. H., Arias J. L., Nicolas J., Couvreur P., Chem. Rev., 2012, 112(11), 5818-5878

[12] Sutton D., Nasongkla N., Blanco E., Gao J. M., Pharm. Res., 2007, 24, 1029—1046

[13] Miyata K., Christie R. J., Kataoka K., React. Funct. Polym., 2011, 71, 227—234

[14] Han M., He C. X., Fang Q. L., Gao J. Q., J. Pharmaceutical Research, 2009, 26(4), 926—935

[15] Gan C. W., Chien S., Feng S. S., J. Curr. Pharm. Design, 2010, 16, 2308—2320

[16] Miao Q. H., Xu D. X., Wang Z., Xu L., Wang T. W., Wu Y., J. Biomaterials, 2010, 31, 7364—7375

[17] Veiseh O., Gunn J. W., Zhang M., Adv. Drug Delivery Rev., 2010, 62(3), 284—304

[18] Ai J., Biazar E., Jafarpour M., Montazeri M., Majdi A., Aminifard S., Zafari M., Akbari H. R., Rad H. G., Int. J. Nanomedicine, 2011, 6, 1117-1127

[19] Dobson J., Drug Dev. Res., 2006, 67, 55—60

[20] Chomoucka J., Drbohlavova J., Huska D., Adam V., Kizek R., Hubalek J., Pharmacol. Res., 2010, 62(2), 144—149

[21] Ding G. B., Guo Y., Lv Y. Y., Liu X. F., Xu L., Zhang X. Z., J. Colloids Surf. B Biointerfaces, 2012, 29(1), 103—109

[22] Ding G. B., Liu H. Y., Lv Y. Y., Liu X. F., Guo Y., Sun C. K., Xu L., Chem. Eur. J., 2012, 18(44), 14037—14046

[23] Heald C. R., Stolnik S., Kujawinski K. S., Matteis C. D., Garnett M. C., Illum L., Davis S. S., Purkiss S. C., Barlow R. J., Gellert P. R., J. Langmuir, 2002, 18(9), 3669-3675

Preparation of Magnetic Drug Carriers with Evodiamine and Fe₃O₄ Nanoparticles Co-encapsulated

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	ZHENG Haijiao, JIANG Liyan, JIA Qiong. Arginine Functionalized Magnetic Nanoparticles and Its Application in Phosphopeptides Enrichment [J]. Chem. J. Chinese Universities, 2021, 42(3): 717.
[2]	LIU Zhihui,QIU Tianyuan,DU Liuyi,YANG Junxing,LIU Kang,WANG Bowei. Preparation and Characterization of Chitosan Alginate Plastic Scaffolds^† [J]. Chem. J. Chinese Universities, 2018, 39(5): 1105.
[3]	LIU Min, WANG Xiuling, LIU Yongjian, CHEN Yongbing, FU Yafeng, ZHOU Xiang. Synthesis and Characterization of Bifunctional Fluorescent Magnetic Fe₃O₄/Alendronate@CdSe/CdS Nanocomposites^† [J]. Chem. J. Chinese Universities, 2015, 36(5): 850.
[4]	LI Tao, ZHANG Long, CHEN Ying, GUO Yajun, DU Xueyan. Preparation and Electromagnetic Wave-absorbing Properties of Micro-polyaniline/Fe₃O₄ Hollow Spheres^† [J]. Chem. J. Chinese Universities, 2015, 36(4): 772.
[5]	ZHANG Xiang, LI Shurun, ZHAI Wentao, CAO Yingze, QI Hongxu, JI Yan, WEI Yen. In Situ Encapsulation of Cellubiase Enzyme in Magnetic Mesoporous Silica via the Nonsurfactant-templated Sol-gel Method^† [J]. Chem. J. Chinese Universities, 2015, 36(11): 2349.
[6]	ZHANG Zhijie, GONG Jiang, TAN Haiying, YAO Kun, TANG Tao. Preparation and Characterization of PS-b-P2VP/Fe₃O₄ Nanocomposites^† [J]. Chem. J. Chinese Universities, 2014, 35(5): 1080.
[7]	ZHAO Tian-Yi, ZHAO Ji-Peng, LEI Li-Yan, CHEN Xiao-Guang, WANG Li-Cheng, CHEN Xue-Si, WANG Li-Ping. Preparation and Bioactivities of DhHP-6-loaded Biodegradable Polymeric Microspheres [J]. Chem. J. Chinese Universities, 2013, 34(1): 236.
[8]	JIANG Ze-Quan, SONG Sheng, DOU Hong-Jing, SUN Kang, WANG Yi-Ming, HUANG Chao-Fan, WEI Zhen-Hua, QU Guan-Xiong. Synthesis of Polycarboxylic Ligand Capped Fe₃O₄ Nanoparticles with Excellent Water-dispersibility via a Ligand-exchange Approach [J]. Chem. J. Chinese Universities, 2012, 33(12): 2609.
[9]	FU Yu, YANG Min, LI Yan, ZHONG Chong-Bin, JIAO Yong-Hua, LIN Ao-Lei. Effect of Layer-by-layer Films of Natural Polymers on Drug Release of Magnetic Poly(lactic acid) Microspheres [J]. Chem. J. Chinese Universities, 2012, 33(12): 2779.
[10]	LIU Xue-Ping, OUYANG Xiang-Yuan, WU Hui-Wang, SHEN Guo-Li, YU Ru-Qin. Novel Fluorescent Technique for Detecting Adenosine Based on DNA Strand Displacement Induced by Target-aptamer Complex and Metal Deposition Catalyzed by Gold Nanoparticles [J]. Chem. J. Chinese Universities, 2012, 33(08): 1692.
[11]	CAO Li-Yan, WANG Hai-Xia, SHI Juan, ZHOU Ye-Hong, LIU Wen-Juan, ZHANG Guo-Mei, SHUANG Shao-Min*. Synthesis and Characterization of Sulfobutylether-β-cyclodextrin/Fe3O4 Hybrid Magnetic Nano-composite [J]. Chem. J. Chinese Universities, 2011, 32(9): 2152.
[12]	SU Peng-Fei, CHEN Guo*, ZHAO Jun. Convenient Preparation and Characterization of Surface Carboxyl-functioned Fe3O4 Magnetic Nanoparticles [J]. Chem. J. Chinese Universities, 2011, 32(7): 1472.
[13]	GAO Qian, ZHANG Ji-Lin, HONG Guang-Yan*, NI Jia-Zuan. Solvothermal Synthesis of the Magnetite Micro-nano Particles(Fe3O4) with Different Morphologies [J]. Chem. J. Chinese Universities, 2011, 32(3): 552.
[14]	WU Li-Yan, WANG Yue-Yi, YANG Dong-Sheng, MENG Qing-Fan, TENG Li-Rong, .... In-situ Synthesis and Properties of Hydroxyapatite-SOD Nanocomposite [J]. Chem. J. Chinese Universities, 2010, 31(8): 1488.
[15]	YANG Guo-Fu, LI Xiang-Hui, ZHAO Zhe, LIU Jia-Kun, WANG Wen-Bo*. Characterization and Tissue Pharmacokinetics in Mice of Arsenic Trioxide Magnetic Nanoparticles [J]. Chem. J. Chinese Universities, 2010, 31(5): 892.