Chem. J. Chinese Universities ›› 2015, Vol. 36 ›› Issue (6): 1156.doi: 10.7503/cjcu20150050
• Physical Chemistry • Previous Articles Next Articles
ZHANG Fada1,2, LIU Yi2,3,*(
), XU Jingcheng2, LI Shengjuan2, WANG Xiunan1,2, SUN Yue2, ZHAO Xinluo3
Received:2015-01-16
Online:2015-06-10
Published:2015-05-22
Contact:
LIU Yi
E-mail:yiliu@shu.edu.cn
Supported by:CLC Number:
TrendMD:
ZHANG Fada, LIU Yi, XU Jingcheng, LI Shengjuan, WANG Xiunan, SUN Yue, ZHAO Xinluo. Molecular Dynamics Study on Binding Strength and Conformation of Dendrimer-based Drug Delivery Systems†[J]. Chem. J. Chinese Universities, 2015, 36(6): 1156.
Fig.1 Atomic structures of CE616@G2(A) snapshot and the structures of the CE616(B) and G2(C) separated from the CE616@G2, respectivelyThe various colors in (B) denote the different drug molecules. All the H atoms are omitted for clarity.
Fig.2 Atomic structures of CE616@G2-PEG(A) snapshot and the structures of the CE616(B) and G2-PEG(C) separated from the CE616@G2-PEG, respectivelyThe various colors in (B) denote the different drug molecules. All the H atoms are omitted for clarity.
Fig.3 Binding energy(Eb) as functions of the number(N) of drug molecules in DN@G2(A) and DN@G2-PEG(B)a. D=CE6; b. D=DOX; c. D=MTX; d. D=SN38.
Fig.4 Instantaneous binding energies(Eb-PD, a), interaction energies(Ei-PD, b), deformation energies(Ed-P, c), and deformation-and-interaction energies(Edi-D, d) of the DN@G2 complexes with CE6(A), DOX(B), MTX(C) and SN38(D) as the functions of the number of drug molecules N
Fig.5 Instantaneous binding energies(Eb-PD, a), interaction energies(Ei-PD, b), deformation energies(Ed-P, c), and deformation-and-interaction(Edi-D, d) energies of the DN@G2-PEG complexes with CE6(A), DOX(B), MTX(C) and SN38(D) as the functions of the number of drug molecules N
| Drug | D1 | D1(D16@G2) | G2 | G2(D16@G2) | D16@G2 | D1(D16@ G2-PEG) | G2-PEG | G2-PEG(D16@ G2-PEG) | D16@G2-PEG |
|---|---|---|---|---|---|---|---|---|---|
| None | 0.896 | 1.965 | |||||||
| CE6 | 0.465 | 0.469±0.05 | 1.294(44.4%) | 1.351(50.8%) | 0.467±0.05 | 2.411(22.7%) | 2.242(14.1%) | ||
| DOX | 0.479 | 0.484±0.07 | 1.314(46.7%) | 1.227(67.0%) | 0.484±0.07 | 2.475(26.0%) | 2.318(18.0%) | ||
| MTX | 0.525 | 0.541±0.42 | 1.228(37.1%) | 1.211(35.2%) | 0.542±0.45 | 2.315(17.8%) | 2.167(10.3%) | ||
| SN38 | 0.434 | 0.434±0.01 | 1.14(27.2%) | 1.189(32.7%) | 0.435±0.01 | 2.36(20.1%) | 2.254(14.7%) |
Table 1 Rg(nm) of drug molecules(D1), dendrimers(G2 or G2-PEG) and drug-dendrimer complexes(DN@G2 or DN@G2-PEG)
| Drug | D1 | D1(D16@G2) | G2 | G2(D16@G2) | D16@G2 | D1(D16@ G2-PEG) | G2-PEG | G2-PEG(D16@ G2-PEG) | D16@G2-PEG |
|---|---|---|---|---|---|---|---|---|---|
| None | 0.896 | 1.965 | |||||||
| CE6 | 0.465 | 0.469±0.05 | 1.294(44.4%) | 1.351(50.8%) | 0.467±0.05 | 2.411(22.7%) | 2.242(14.1%) | ||
| DOX | 0.479 | 0.484±0.07 | 1.314(46.7%) | 1.227(67.0%) | 0.484±0.07 | 2.475(26.0%) | 2.318(18.0%) | ||
| MTX | 0.525 | 0.541±0.42 | 1.228(37.1%) | 1.211(35.2%) | 0.542±0.45 | 2.315(17.8%) | 2.167(10.3%) | ||
| SN38 | 0.434 | 0.434±0.01 | 1.14(27.2%) | 1.189(32.7%) | 0.435±0.01 | 2.36(20.1%) | 2.254(14.7%) |
Fig.6 Radius of gyration(Rg) as functions of number of drug molecules in DN@G2(A) and DN@G2-PEG(B) with CE6(a), DOX(b), MTX(c) and SN38(d), respectively
Fig.7 Rg of DN@PAMAM [D=CE6(A), DOX(B), MTX(C) and SN38(D)] as functions of PAMAM generation(G0—G3)
| DN@Gn | Eb(H2O)/ (kJ·mol-1) | Eb(no H2O)/ (kJ·mol-1) | DN@Gn-PEG | Eb(H2O)/ (kJ·mol-1) | Eb(no H2O)/ (kJ·mol-1) |
|---|---|---|---|---|---|
| CE68@G0 | -218.572 | -98.157 | CE68@G0-PEG | 154.808 | -138.951 |
| DOX8@G0 | -201.418 | -111.587 | DOX8@G0-PEG | 118.407 | -146.900 |
| MTX8@G0 | -205.476 | -82.299 | MTX8@G0-PEG | 166.900 | -145.478 |
| SN388@G0 | -137.277 | -84.224 | SN388@G0-PEG | 212.464 | -125.813 |
| CE610@G1 | -254.136 | -109.412 | CE612@G1-PEG | 224.555 | -144.766 |
| DOX10@G1 | -148.699 | -125.478 | DOX12@G1-PEG | 364.719 | -129.160 |
| MTX10@G1 | -210.079 | -101.546 | MTX12@G1-PEG | 301.834 | -112.089 |
| SN3810@G1 | -90.709 | -96.650 | SN3812@G1-PEG | 346.017 | -142.047 |
| CE616@G2 | -213.761 | -122.089 | CE616@G2-PEG | 378.610 | -141.126 |
| DOX16@G2 | -195.351 | -137.612 | DOX16@G2-PEG | 533.251 | -119.077 |
| MTX16@G2 | 114.683 | -115.060 | MTX16@G2-PEG | 486.265 | -136.608 |
| SN3816@G2 | -109.746 | -103.721 | SN3816@G2-PEG | -632.788 | -88.408 |
Table 2 Binding energy(Eb) of DN@PAMAM complexes with(or without) water
| DN@Gn | Eb(H2O)/ (kJ·mol-1) | Eb(no H2O)/ (kJ·mol-1) | DN@Gn-PEG | Eb(H2O)/ (kJ·mol-1) | Eb(no H2O)/ (kJ·mol-1) |
|---|---|---|---|---|---|
| CE68@G0 | -218.572 | -98.157 | CE68@G0-PEG | 154.808 | -138.951 |
| DOX8@G0 | -201.418 | -111.587 | DOX8@G0-PEG | 118.407 | -146.900 |
| MTX8@G0 | -205.476 | -82.299 | MTX8@G0-PEG | 166.900 | -145.478 |
| SN388@G0 | -137.277 | -84.224 | SN388@G0-PEG | 212.464 | -125.813 |
| CE610@G1 | -254.136 | -109.412 | CE612@G1-PEG | 224.555 | -144.766 |
| DOX10@G1 | -148.699 | -125.478 | DOX12@G1-PEG | 364.719 | -129.160 |
| MTX10@G1 | -210.079 | -101.546 | MTX12@G1-PEG | 301.834 | -112.089 |
| SN3810@G1 | -90.709 | -96.650 | SN3812@G1-PEG | 346.017 | -142.047 |
| CE616@G2 | -213.761 | -122.089 | CE616@G2-PEG | 378.610 | -141.126 |
| DOX16@G2 | -195.351 | -137.612 | DOX16@G2-PEG | 533.251 | -119.077 |
| MTX16@G2 | 114.683 | -115.060 | MTX16@G2-PEG | 486.265 | -136.608 |
| SN3816@G2 | -109.746 | -103.721 | SN3816@G2-PEG | -632.788 | -88.408 |
| DN@Gn | Ei-PD(H2O)/ (kJ·mol-1) | Ei-PD(no H2O)/ (kJ·mol-1) | DN@Gn-PEG | Ei-PD(H2O)/ (kJ·mol-1) | Eb(no H2O)/ (kJ·mol-1) |
|---|---|---|---|---|---|
| CE68@G0 | -161.126 | -37.447 | CE68@G0-PEG | -204.137 | -106.734 |
| DOX8@G0 | -174.389 | -20.209 | DOX8@G0-PEG | -253.969 | -133.260 |
| MTX8@G0 | -175.770 | -29.079 | MTX8@G0-PEG | -195.184 | -161.377 |
| SN388@G0 | -122.591 | -21.255 | SN388@G0-PEG | -167.862 | -130.708 |
| CE610@G1 | -164.640 | -54.057 | CE612@G1-PEG | -193.970 | -153.929 |
| DOX10@G1 | -182.841 | -54.099 | DOX12@G1-PEG | -192.087 | -165.184 |
| MTX10@G1 | -157.151 | -42.802 | MTX12@G1-PEG | -177.694 | -153.595 |
| SN3810@G1 | -121.545 | -40.417 | SN3812@G1-PEG | -120.792 | -93.430 |
| CE616@G2 | -153.678 | -60.250 | CE616@G2-PEG | -230.204 | -205.476 |
| DOX16@G2 | -173.887 | -69.036 | DOX16@G2-PEG | -212.589 | -151.586 |
| MTX16@G2 | -194.472 | -59.329 | MTX16@G2-PEG | -192.004 | -178.950 |
| SN3816@G2 | -121.503 | -49.162 | SN3816@G2-PEG | -162.088 | -133.553 |
Table 3 Interaction energies(Ei-PD) of DN@PAMAM complexes with(or without) water
| DN@Gn | Ei-PD(H2O)/ (kJ·mol-1) | Ei-PD(no H2O)/ (kJ·mol-1) | DN@Gn-PEG | Ei-PD(H2O)/ (kJ·mol-1) | Eb(no H2O)/ (kJ·mol-1) |
|---|---|---|---|---|---|
| CE68@G0 | -161.126 | -37.447 | CE68@G0-PEG | -204.137 | -106.734 |
| DOX8@G0 | -174.389 | -20.209 | DOX8@G0-PEG | -253.969 | -133.260 |
| MTX8@G0 | -175.770 | -29.079 | MTX8@G0-PEG | -195.184 | -161.377 |
| SN388@G0 | -122.591 | -21.255 | SN388@G0-PEG | -167.862 | -130.708 |
| CE610@G1 | -164.640 | -54.057 | CE612@G1-PEG | -193.970 | -153.929 |
| DOX10@G1 | -182.841 | -54.099 | DOX12@G1-PEG | -192.087 | -165.184 |
| MTX10@G1 | -157.151 | -42.802 | MTX12@G1-PEG | -177.694 | -153.595 |
| SN3810@G1 | -121.545 | -40.417 | SN3812@G1-PEG | -120.792 | -93.430 |
| CE616@G2 | -153.678 | -60.250 | CE616@G2-PEG | -230.204 | -205.476 |
| DOX16@G2 | -173.887 | -69.036 | DOX16@G2-PEG | -212.589 | -151.586 |
| MTX16@G2 | -194.472 | -59.329 | MTX16@G2-PEG | -192.004 | -178.950 |
| SN3816@G2 | -121.503 | -49.162 | SN3816@G2-PEG | -162.088 | -133.553 |
| DN@Gn | D/(nm2·ps-1) | DN@Gn-PEG | D/(nm2·ps-1) |
|---|---|---|---|
| CE68@G0 | 1.1×10-3 | CE68@G0-PEG | 6.4×10-4 |
| DOX8@G0 | 1.0×10-3 | DOX8@G0-PEG | 8.1×10-4 |
| MTX8@G0 | 1.0×10-3 | MTX8@G0-PEG | 8.8×10-4 |
| SN388@G0 | 9.6×10-4 | SN388@G0-PEG | 7.5×10-4 |
| CE610@G1 | 7.8×10-4 | CE612@G1-PEG | 7.0×10-4 |
| DOX10@G1 | 8.7×10-4 | DOX12@G1-PEG | 7.0×10-4 |
| MTX10@G1 | 1.2×10-3 | MTX12@G1-PEG | 7.9×10-4 |
| SN3810@G1 | 1.2×10-3 | SN3812@G1-PEG | 5.7×10-4 |
| CE616@G2 | 8.8×10-4 | CE616@G2-PEG | 5.0×10-4 |
| DOX16@G2 | 7.1×10-4 | DOX16@G2-PEG | 5.1×10-4 |
| MTX16@G2 | 6.6×10-4 | MTX16@G2-PEG | 5.5×10-4 |
| SN3816@G2 | 7.7×10-4 | SN3816@G2-PEG | 3.2×10-4 |
Table 4 Diffusion coefficients(D) of the DN@Gn and DN@Gn-PEG complexes in water
| DN@Gn | D/(nm2·ps-1) | DN@Gn-PEG | D/(nm2·ps-1) |
|---|---|---|---|
| CE68@G0 | 1.1×10-3 | CE68@G0-PEG | 6.4×10-4 |
| DOX8@G0 | 1.0×10-3 | DOX8@G0-PEG | 8.1×10-4 |
| MTX8@G0 | 1.0×10-3 | MTX8@G0-PEG | 8.8×10-4 |
| SN388@G0 | 9.6×10-4 | SN388@G0-PEG | 7.5×10-4 |
| CE610@G1 | 7.8×10-4 | CE612@G1-PEG | 7.0×10-4 |
| DOX10@G1 | 8.7×10-4 | DOX12@G1-PEG | 7.0×10-4 |
| MTX10@G1 | 1.2×10-3 | MTX12@G1-PEG | 7.9×10-4 |
| SN3810@G1 | 1.2×10-3 | SN3812@G1-PEG | 5.7×10-4 |
| CE616@G2 | 8.8×10-4 | CE616@G2-PEG | 5.0×10-4 |
| DOX16@G2 | 7.1×10-4 | DOX16@G2-PEG | 5.1×10-4 |
| MTX16@G2 | 6.6×10-4 | MTX16@G2-PEG | 5.5×10-4 |
| SN3816@G2 | 7.7×10-4 | SN3816@G2-PEG | 3.2×10-4 |
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