Stability and Release Properties of Drug-loaded Pickering Emulsions by the Modified Sodium Alginate Activated SiO2 Nanoparticles

doi:10.7503/cjcu20130299

Abstract

Abstract:

Pickering emulsions(W/O) loaded cyhalothrins were prepared by SiO₂ nanoparticles whose surface were activated using amphiphilic alginate derivative hydrophobically modified by cholesterol under the conditions of high speed stirring. And they were characterized by means of Fourier transform infrared spectroscopy(FTIR),¹H nuclear magnetic resonance(¹H NMR), fluorescence spectrum, dynamic light scattering, optical microscope and release studies. Experimental results showed that cholesterol groups had successfully grafted to the alginate molecular chains. The critical aggregation concentration of modified alginate was reduced from 1.26 mg/L to 0.28 mg/L, which showed good amphipathy. Alginate derivative(CSAD) and surfactant CTAB could be also adsorbed on the surface of SiO₂ nanoparticles with the corresponding zeta potential which were 16.4 and -30.7 mV, respectively. And the particle sizes were 583.3 and 438.4 nm, respectively. The release rate of the Pickering emulsions prepared by the SiO₂ particles activated by CSAD was more slowly. That may be the cross-linking action of CSAD which made the activated SiO₂ particles adsorbed on the oil-water interface form the relatively stable network structures or the interface membranes.

Key words: Cyhalothrin, Sodium alginate, Cholesterol, Amphipathic, Pickering emulsion, SiO₂ nano-particles, Cholesteryl grafted sodium alginate derivative(CSAD)

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TrendMD:

YAN Hui-Qiong, LI Jia-Cheng, FENG Yu-Hong, HU Wen-Tao, LIU Ruo-Lin, LIN Qiang. Stability and Release Properties of Drug-loaded Pickering Emulsions by the Modified Sodium Alginate Activated SiO₂ Nanoparticles[J]. Chem. J. Chinese Universities, 2013, 34(9): 2164.

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Stability and Release Properties of Drug-loaded Pickering Emulsions by the Modified Sodium Alginate Activated SiO₂ Nanoparticles

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