Microwave-assisted Synthesis of Arene Ru(Ⅱ) Complex [(η6-C6H6)Ru(H2iiP)Cl]Cl in SiC Vessel

doi:10.7503/cjcu20121112

Abstract

Abstract:

Arene Ru(Ⅱ) complex [(η⁶-C₆H₆)Ru(H₂iiP)Cl]Cl(1) was synthesized using [(η⁶-C₆H₆)·5RuCl₂]₂ and 2-indole-3-imidazole[4,5-f][1,10] phenanthroline(H₂iiP) as raw material under microwave irradiation. The target compound was characterized by means of elemental analysis, ESI-MS, IR and NMR. The best craft condition determined by orthogonal test is that reactant molar ratio of 1.0: 2.2, the reaction tempe-rature of 90℃ and the microwave irradiation time of 30 min. Then the average yield of 96.0% and RSD of 1.28% confirmed that microwave-assisted synthesis of arene Ru(Ⅱ) complex in SiC vessel gives a good stability and reiteration. The antitumor activity of arene Ru(Ⅱ) complex 1 was determined by MTT assay and the results showed that complex 1 could selectively inhibit the growth of MCF-7, indicating its potential utility in chemotherapy.

Key words: 2-Indole-3-imidazole[4,5-f][1,10]phenanthroline(H₂iiP), Arene Ru(Ⅱ) complex, SiC vessel, Microwave-assisted synthesis, Antitumor

CLC Number:

O626.23

TrendMD:

WU Qiong, MEI Wen-Jie, WU Wei-Li, CHEN Yan-Hua, ZENG Ling-Li, ZHENG Wen-Jie. Microwave-assisted Synthesis of Arene Ru(Ⅱ) Complex [(η⁶-C₆H₆)Ru(H₂iiP)Cl]Cl in SiC Vessel[J]. Chem. J. Chinese Universities, 2013, 34(8): 1863.

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Microwave-assisted Synthesis of Arene Ru(Ⅱ) Complex [(η⁶-C₆H₆)Ru(H₂iiP)Cl]Cl in SiC Vessel

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