Application of Zwitterionic Polymers in the Treatment of Malignant Tumors†

doi:10.7503/cjcu20150608

Abstract

Abstract:

Zwitterionic polymer is a kind of polymer both with acidic and basic groups, which exists in the form of zwitterion. Zwitterionic polymers have attracted our widespread attention because of the excellent performance of themselves, such as high hydration ability, significant anti-bacterial adhesion ability, charge conversion, be easily modified and so on. In this review, the variety of zwitterionic polymers will be classified according to the structure. The early diagnosis and treatment of malignant tumors by zwitterionic polymers were analyzed and summarized in this paper. Finally, the development of zwitterionic polymers in future is prospected.

Key words: Zwitterionic polymer, Drug delivery, Gene delivery, Medical diagnosis, Antitumor

TrendMD:

CHEN Jie, LI Xiaozhou, TIAN Huayu, ZHU Xiaojuan, CHEN Xuesi. Application of Zwitterionic Polymers in the Treatment of Malignant Tumors^†[J]. Chem. J. Chinese Universities, 2015, 36(11): 2148.

Figures/Tables 8

Fig.1 Different skeleton structures of zwitterionic polymers

Fig.2 Synthesis of P(Glu-co-Lys) polypeptide[24] Copyright from American Chemical Society.

Fig.3 pH-responsive zwitterionic copolypeptides as charge conversional shielding system for gene carriers[10] Copyright from Elsevier B.V.

Fig.4 Chemical structure of the zwitterionic polymer and its application as a novel drug delivery system[27] Copyright from American Chemical Society.

Fig.5 Zwitterionic polymer-coated immunobeads for diagnostics[35] (A) Structure of the zwitterioinc polymers; (B) polymers are adsorbed directly onto the surfaces of the SiO2; (C) NHS esters are introduced onto the terminal carboxylic acids of the zwitterionic polymers; (D) IgG antibodies are conjugated to NHS esters. Copyright from American Chemical Society.

Fig.6 Preparation of PLGA-PCB copolymers, the formation of PLGA-PCB/Docetaxel NPs, and the functionalization of NPs with targeting ligands or diagnostic dyes[44] Copyright from Wiley-VCH Verlag GmbH&Co. KGaA, Weinheim.

Fig.7 Schematic illustration of zwitterionic based gene delivery system[53] Copyright from Wiley-VCH Verlag GmbH&Co. KGaA, Weinheim.

Fig.8 Scheme of the zwitterionic based drug and gene codelivery system for cancer therapy[58] Copyright from American Chemical Society.

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