Molecular Recognition Mechanism of Chiral (S)-Ibuprofen’s Hydrogen Bonds Self-assembly Imprinted Polymer

doi:10.3969/j.issn.0251-0790.2012.04.034

Abstract

Abstract: A series of imprinted polymer was synthesized using chiral (S)-ibuprofen with a single polarity group as the template molecular. The calculated results of UV indicated the complex ratio of host-guest was 1: 1. IR analysis result revealed in the pre-assembly process and re-adsorption process, the blue-shifted hydrogen bonds and red-shift hydrogen bonds were formed between template molecule and functional monomer, respectively. The isotherm results indicated that the specificity binding capacity was 37.92 μmol/g, and the imprinted factor of the polymer was 3.06. The chiral separation experiment indicated that compared with (R)-ibuprofen, (S)-ibuprofen template polymer exhibited significant adsorption selectivity for (S)-ibuprofen. Also, the separation factor was 1.79.

Key words: Imprinting mechanism, Three-dimensional structure, Hydrogen bond, Imprinted factor, (S)-Ibuprofen(Ed.: W, Z)

CLC Number:

O631
O657

TrendMD:

SUN Yan, WANG Bing. Molecular Recognition Mechanism of Chiral (S)-Ibuprofen’s Hydrogen Bonds Self-assembly Imprinted Polymer[J]. Chem. J. Chinese Universities, 2012, 33(04): 838.

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