关键词: (Z)-3-丁烯基-4-羟基苯酞, 苯酞, 3-丙基-5-羟基异香豆素, 异香豆素, 合成

Abstract: (Z)-3-Butylidene-4-hydroxyphthalide(1)was prepared from 2-formyl-3-methoxy benzoic acid(2).2 was converted to 2-pentenyl-3-methoxybenzoic acid(4)by the usual method.4 was dissolved in sodium bicarbonate solution and reacted with a solution of iodine in aqueous potassium iodide to give 5 and 6,which was converted to 3-propyl-5-hydroxyiso coumarine(3)by the conventional method.Iodophthalide(5)was treated with sodium acetate to furnish(Z)-3-butylidene-4-methoxyphthalide(7).Demethylation of 7 was conducted with boron tribromide to give the title compound(1).The overall yield of 1 is 46%.

Key words: (Z)-3-Butylidene-4-hydroxyphthalide, Phthalide, 3-Propyl-5-hydroxyiso-Coumarin, Isocoumarin, Synthesis