高等学校化学学报

高等学校化学学报 ›› 1995, Vol. 16 ›› Issue (2): 237.

• 研究简报 • 上一篇    下一篇

11-氯代青蒿素的合成及其构型的确定

陆德文, 李英   

  1. 中国科学院上海药物研究所, 上海 200031
  • 收稿日期:1994-05-12 修回日期:1994-09-10 出版日期:1995-02-24 发布日期:1995-02-24
  • 通讯作者: 李英
  • 作者简介:陆德文,男,55岁,现在常熟高等专科学校化学系.

Synthesis and Configurational Determination of 11-Chloroartemisinin

LU De-Wen, LI Ying   

  1. Shanghai Institute of Materia Medica, Academia Sinica, Shanghai, 200031
  • Received:1994-05-12 Revised:1994-09-10 Online:1995-02-24 Published:1995-02-24

PDF (PC)

被引次数

2

关键词: 11-氯代青蒿素, 合成, 构型

Abstract: Chloroartemisinin,a new derivative of artemisinin,was prepared by treating 11α-hydroxyartemisinin with SOCl2/Pyr with retention of configuration.11-Chloro atom having α orientation was determinated by NMR technique and molecular mechanic calculation.

Key words: 11-Chloroartemisinin, Synthesis, Configuration

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