高等学校化学学报

高等学校化学学报

• 研究论文 • 上一篇    下一篇

基于红光碳点光敏剂的活性收缩水凝胶用于细菌感染的伤口愈合

郝永梁1,2，李 建1,2，王泽华1,2，葛介超1,2   

  1. 1.中国科学院理化技术研究所 光化学转换与功能材料重点实验室 2.中国科学院大学 未来技术学院
  • 收稿日期:2024-08-30 修回日期:2024-09-23 出版日期:2024-10-08 发布日期:2024-10-08
  • 通讯作者: 葛介超 E-mail:jchge2010@mail.ipc.ac.cn
  • 基金资助:
    国家自然科学基金（批准号：52272052）和国家重点研发计划（批准号：2022YFA1207600）资助

Active shrinkage hydrogel based on red emissive carbon dots photosensitizers for bacterial infected wound healing

HAO Yongliang1,2, LI Jian1,2, WANG Zehua1,2, GE Jiechao1,2   

  1. 1.  Key Laboratory of Photochemical Conversion and Optoelectronic Materials，Technical Institute of Physics and Chemistry，Chinese Academy of Sciences

     2. School of Future Technology，University of Chinese Academy of Sciences
  • Received:2024-08-30 Revised:2024-09-23 Online:2024-10-08 Published:2024-10-08
  • Contact: Jiechao Ge E-mail:jchge2010@mail.ipc.ac.cn
  • Supported by:
     National Natural Science Foundation of China (No. 52272052) and the Project of the National Key Research and Development Program of China (No. 2022YFA1207600)

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摘要： 本工作设计制备了一种基于红光碳点光敏剂的活性收缩水凝胶（PNSP Gel），用于细菌感染的伤口愈合。 PNSP Gel以N-异丙基丙烯酰胺（NIPAM）、海藻酸钠（SA）和碳点（CDs）光敏剂为主要原料，通过自由基聚合和钙离子交联的方法制备而成。PNSP Gel能够在体温下（37 ℃）通过活性收缩作用释放出CDs光敏剂，进一步通过CDs光敏剂的光动力抗菌作用，有效杀灭伤口部位的细菌，促进伤口的快速愈合。研究结果表明，PNSP Gel具有良好的释药性能、光动力抗菌性能以及加速伤口愈合的能力，为临床伤口管理提供了一种新的解决方案。

关键词:  , 碳点；光动力抗菌；水凝胶；伤口愈合

Abstract: An active shrinkage hydrogel based on red emissive carbon dots (CDs) photosensitizers (PSs) was developed for bacterial infected wound healing. The hydrogel was prepared by using N-isopropylacrylamide (NIPAM), sodium alginate (SA) and CDs PSs as precursors through free radical polymerization and calcium ion cross-linking. The hydrogel could release CDs PSs at body temperature (37 ℃) due to the active shrinkage of hydrogel. Upon light irradiation, the released CDs PSs can generate singlet oxygen to kills bacteria effectively in the wound site leading to the rapid wound healing. In vitro and in vivo results suggest that the developed active shrinkage hydrogel have good drug release, photodynamic antibacterial effects and the ability to accelerate wound healing, thus providing a new type of hydrogel for clinical wound management.

Key words: Carbon dots, Photodynamic antibacterial, Hydrogel, Wound healing

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