高等学校化学学报

高等学校化学学报

• 研究论文 • 上一篇    下一篇

抗氧化碳点用于对乙酰氨基苯酚诱导的急性肝损伤的改善

李燕,蔡皓,毕红   

  1. 安徽大学材料科学与工程学院，合肥 230601
  • 收稿日期:2024-03-20 修回日期:2024-05-07 出版日期:2024-05-15 发布日期:2024-05-15
  • 通讯作者: 毕红 E-mail:bihong@ahu.edu.cn
  • 基金资助:
    国家自然科学基金(批准号：52172033)和国家重点研发计划(批准号：2021YFA1600202)资助.

Antioxidative Carbon Dots Improving Acute Liver Injury Induced by Acetaminophen

LI Yan, CAI Hao, BI Hong   

  1. College of Materials Science and Engineering, Anhui University, Hefei 230601, China
  • Received:2024-03-20 Revised:2024-05-07 Online:2024-05-15 Published:2024-05-15
  • Contact: BI Hong E-mail:bihong@ahu.edu.cn
  • Supported by:
    Supported by the National Natural Science Foundation of China(No. 52172033) and the National Key Research and Development Program of China(No. 2021YFA1600202).

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摘要： 对乙酰氨基苯酚(APAP)是一种用于治疗头疼和发烧症状的药物，其代谢产物会消耗肝脏内的谷胱甘肽(GSH)，引起氧化应激. 短时间内大量服用APAP，会导致肝功能衰竭. 本研究以邻苯二酚(CAT)和2，5-二羟基对苯二甲酸(DHTA)为前驱体，采用一步水热法合成了具有强抗氧化能力和良好的生物相容性的黄光碳点(D-CDs). 在斑马鱼APAP损伤肝损伤模型中，体内成像显示D-CDs可以有效富集在斑马鱼肝脏部位，提高斑马鱼体内的超氧化物歧化酶(SOD)活性、谷胱甘肽(GSH)含量，并降低丙二醛(MDA)水平，有效改善由APAP所引起的氧化应激损伤.

关键词: 碳点, 抗氧化, 对乙酰氨基苯酚, 肝损伤, 斑马鱼

Abstract: Acetaminophen (APAP) is a drug used to treat headaches and fever symptoms, Its metabolites deplete glutathione (GSH) in the liver and cause oxidative stress. Taking large amounts of APAP in a short period of time can lead to liver failure. In this study, yellow-emissive carbon dots (D-CDs) with strong antioxidant ability and good biocompatibility were synthesized by one-step hydrothermal method using catechol (CAT) and 2, 5-dihydroxyterephthalic acid (DHTA) as precursors. In the APAP-induced zebrafish liver injury model, in vivo imaging showed that D-CDs could be effectively enriched in the zebrafish liver, increase the superoxide dismutase (SOD) activity and glutathione (GSH) content, and reduce the level of malondialdehyde (MDA), which finally effectively improve APAP-induced oxidative stress injury in zebrafish.

Key words: Carbon dots, Antioxidant, Acetaminophen, Liver injury, Zebrafish

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