高等学校化学学报

高等学校化学学报

• 研究论文 • 上一篇    下一篇

红光发射线粒体靶向铁掺杂碳点通过类过氧化物酶活性诱导铁死亡进行肿瘤治疗

薛小矿1,2，李建1,2，梁焕仪1,2，王一颖3，葛介超1,2   

  1. 1. 中国科学院理化技术研究所 2. 中国科学院大学未来技术学院 3. 天津市人民医院
  • 收稿日期:2025-04-02 修回日期:2025-04-11 网络首发:2025-04-28 发布日期:2025-04-28
  • 通讯作者: 葛介超

Red-Emissive Mitochondria-Targeting Iron-Doped Carbon Dots for Tumor Therapy via Peroxidase-Mimicking Activity-Induced Ferroptosis

XUE Xiaokuang1,2, LI Jian1,2, LIANG Huanyi1,2, WANG Yiying3, GE Jiechao1,2   

  1. 1. Technical Institute of Physics and Chemistry, Chinese Academy of Sciences 2. School of Future Technology, University of Chinese Academy of Sciences 3. Tianjin People's Hospital,
  • Received:2025-04-02 Revised:2025-04-11 Online First:2025-04-28 Published:2025-04-28
  • Contact: Jiechao Ge

PDF (PC)

补充材料

1

摘要： 本研究合成了具有强类过氧化物酶活性的铁掺杂碳点（Fe-CDs）用于肿瘤特异性治疗。其固有的红色荧光能够实现高对比度的细胞成像，揭示其聚集在线粒体。在富含过氧化氢（H2O2）的酸性肿瘤微环境中，Fe-CDs催化羟基自由基（·OH）生成，诱导脂质过氧化，最终触发铁死亡。体内外实验均表明，Fe-CDs对肿瘤具有显著的抑制作用。此外，Fe-CDs表现出优异的生物相容性，未见明显的全身毒性。通过结合荧光成像与催化治疗，本研究为肿瘤治疗和铁死亡研究提供了一个有前景的新策略。

关键词: 碳点, 纳米酶, 线粒体靶向, 铁死亡, 肿瘤治疗

Abstract: In this study, iron-doped carbon dots (Fe-CDs) with strong peroxidase-mimicking activity were synthesized for tumor-specific therapy. Their intrinsic red fluorescence enabled high-contrast cellular imaging, revealing preferential mitochondrial accumulation. In the acidic, hydrogen peroxide (H2O2)-rich tumor microenvironment, Fe-CDs catalyzed hydroxyl radical (·OH) generation, inducing oxidative stress and lipid peroxidation, ultimately triggering ferroptosis. In vitro and in vivo studies demonstrated potent tumor inhibition. Furthermore, Fe-CDs exhibited excellent biocompatibility with no significant systemic toxicity. By integrating fluorescence imaging and catalytic therapy, this study presents a promising nanoplatform for tumor treatment and ferroptosis research.

Key words: Carbon Dots, Nanozyme; Mitochondria-Targeting, Ferroptosis, Tumor Therapy

中图分类号: 

TrendMD: