高等学校化学学报 ›› 2011, Vol. 32 ›› Issue (9): 2022.

• 综合评述 • 上一篇    下一篇

瓜环类超分子药物载体的研究进展

黄英1,2,陶朱1,薛赛凤1,祝黔江1   

  1. 1. 贵州大学贵州省大环化学及超分子化学重点实验室,
    2. 西南药用生物资源教育部工程研究中心, 贵阳  550025
  • 收稿日期:2011-03-29 修回日期:2011-05-09 出版日期:2011-09-10 发布日期:2011-08-11
  • 通讯作者: 陶朱 E-mail:gzutao@263.net
  • 基金资助:

    国家自然科学基金(批准号: 20972034)、 贵州省省长资金(批准号:  黔省专合字(2009)103号)、 贵州省科技厅自然科学基金(批准号: 黔科合J字[2009]2288号)、 贵州省教育厅自然科学基金(批准号: 黔教科2010013)和贵州大学引进人才项目[批准号: 贵大人基合字(2009)023号]资助.

Progress of Cucurbit[n]urils in Drug Delivery System

HUANG Ying1,2, TAO Zhu1*, XUE Sai-Feng1, ZHU Qian-Jiang1   

  1. 1. Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province,
    2. Engineering and Research Center for Southwest Bio\|pharmaceutical Resources,  Ministry of Education, Guizhou University, Guiyang 550025, China
  • Received:2011-03-29 Revised:2011-05-09 Online:2011-09-10 Published:2011-08-11
  • Contact: TAO Zhu E-mail:gzutao@263.net
  • Supported by:

    国家自然科学基金(批准号: 20972034)、 贵州省省长资金(批准号:  黔省专合字(2009)103号)、 贵州省科技厅自然科学基金(批准号: 黔科合J字[2009]2288号)、 贵州省教育厅自然科学基金(批准号: 黔教科2010013)和贵州大学引进人才项目[批准号: 贵大人基合字(2009)023号]资助.

摘要: 瓜环具有“内疏水、外亲水”的特殊分子结构,可以多种有机物发生主客体相互作用而形成自组装分子胶囊或超分子实体,使其在环境、医药、化学分离、材料的改性等方面都有着广泛的应用前景。本文结合自己的工作,参考国内外文献综述了瓜环在药物载体及药物传输方面的研究进展,并就瓜环在药物领域的发展作一展望。

关键词: 瓜环, 药物载体, 药物传输

Abstract: As a type of novel synthetic acceptor, cucurbit[n]urils(Q[n]s) which has the unique structure with hydrophobic central cavity and hydrophilic carbonyl group portals, can selectively bind different guest molecules to form self-assembly host-guest complexes, capsules and supramolecular entities. Thus, cucurbit[n]uril could be used in many different fields, such as environment, pharmacology, separation and material. Combining with our researches and referring other works from literatures, this paper reviewed the recent advance of cucurbiturils in the drug carriers and drug delivery, and the prospect of the cucurbituril in pharmacology were also presented.

Key words: Cucurbit[n]uril, Drug carrier, Drug delivery

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