两性离子聚合物在恶性肿瘤治疗中的应用

doi:10.7503/cjcu20150608

高等学校化学学报 ›› 2015, Vol. 36 ›› Issue (11): 2148.doi: 10.7503/cjcu20150608

两性离子聚合物在恶性肿瘤治疗中的应用

陈杰¹, 李小舟^1,², 田华雨¹(), 朱筱娟², 陈学思¹

1. 中国科学院长春应用化学研究所生态环境高分子材料重点实验室, 长春 130022
2. 东北师范大学生命科学学院, 长春 130024

收稿日期:2015-08-03 出版日期:2015-11-10 发布日期:2015-10-16
作者简介:联系人简介: 田华雨, 男, 博士, 研究员. 主要从事高分子基因载体研究. E-mail:thy@ciac.ac.cn
基金资助:
国家自然科学基金(批准号: 51303173, 51390484, 21474104, 51403205和51222307)、吉林省科技发展项目(批准号: 20130521011JH)和国家高技术研究发展计划(批准号: 2014AA020708)资助

Application of Zwitterionic Polymers in the Treatment of Malignant Tumors^†

CHEN Jie¹, LI Xiaozhou^1,², TIAN Huayu^1,^*(), ZHU Xiaojuan², CHEN Xuesi¹

1. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry,Chinese Academy of Sciences, Changchun 130022, China
2. Institute of Cytology and Genetics, Key Laboratory of Molecular Epigenetics of Ministry of Education,Northeast Normal University, Changchun 130024, China

Received:2015-08-03 Online:2015-11-10 Published:2015-10-16
Contact: TIAN Huayu E-mail:thy@ciac.ac.cn
Supported by:
† Supported by the National Natural Science Foundation of China(Nos.51303173, 51390484, 21474104, 51403205, 51222307), the Jilin Province Science and Technology Development Program of China(No.20130521011JH) and the Project of National High Tech.R&D Program of China(No.2014AA020708)

摘要/Abstract

摘要：

两性离子聚合物是一类同时具有酸性和碱性基团的聚合物, 在特定pH环境以两性离子的形式存在.两性离子聚合物以水化性能强、抗细菌黏附能力显著、可电荷翻转及易化学修饰等优异性能引起了人们的广泛关注. 本文主要根据两性离子聚合物的结构进行分类, 并对其在恶性肿瘤的早期诊断和治疗领域的研究进行了分析和总结, 展望了两性离子聚合物的发展前景.

关键词: 两性离子聚合物, 药物传输, 基因传递, 医学诊断, 抗肿瘤

Abstract:

Zwitterionic polymer is a kind of polymer both with acidic and basic groups, which exists in the form of zwitterion. Zwitterionic polymers have attracted our widespread attention because of the excellent performance of themselves, such as high hydration ability, significant anti-bacterial adhesion ability, charge conversion, be easily modified and so on. In this review, the variety of zwitterionic polymers will be classified according to the structure. The early diagnosis and treatment of malignant tumors by zwitterionic polymers were analyzed and summarized in this paper. Finally, the development of zwitterionic polymers in future is prospected.

Key words: Zwitterionic polymer, Drug delivery, Gene delivery, Medical diagnosis, Antitumor

TrendMD:

陈杰, 李小舟, 田华雨, 朱筱娟, 陈学思. 两性离子聚合物在恶性肿瘤治疗中的应用. 高等学校化学学报, 2015, 36(11): 2148.

CHEN Jie, LI Xiaozhou, TIAN Huayu, ZHU Xiaojuan, CHEN Xuesi. Application of Zwitterionic Polymers in the Treatment of Malignant Tumors^†. Chem. J. Chinese Universities, 2015, 36(11): 2148.

图/表 8

Fig.1 Different skeleton structures of zwitterionic polymers

Fig.2 Synthesis of P(Glu-co-Lys) polypeptide[24] Copyright from American Chemical Society.

Fig.3 pH-responsive zwitterionic copolypeptides as charge conversional shielding system for gene carriers[10] Copyright from Elsevier B.V.

Fig.4 Chemical structure of the zwitterionic polymer and its application as a novel drug delivery system[27] Copyright from American Chemical Society.

Fig.5 Zwitterionic polymer-coated immunobeads for diagnostics[35] (A) Structure of the zwitterioinc polymers; (B) polymers are adsorbed directly onto the surfaces of the SiO2; (C) NHS esters are introduced onto the terminal carboxylic acids of the zwitterionic polymers; (D) IgG antibodies are conjugated to NHS esters. Copyright from American Chemical Society.

Fig.6 Preparation of PLGA-PCB copolymers, the formation of PLGA-PCB/Docetaxel NPs, and the functionalization of NPs with targeting ligands or diagnostic dyes[44] Copyright from Wiley-VCH Verlag GmbH&Co. KGaA, Weinheim.

Fig.7 Schematic illustration of zwitterionic based gene delivery system[53] Copyright from Wiley-VCH Verlag GmbH&Co. KGaA, Weinheim.

Fig.8 Scheme of the zwitterionic based drug and gene codelivery system for cancer therapy[58] Copyright from American Chemical Society.

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两性离子聚合物在恶性肿瘤治疗中的应用

Application of Zwitterionic Polymers in the Treatment of Malignant Tumors^†

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两性离子聚合物在恶性肿瘤治疗中的应用

Application of Zwitterionic Polymers in the Treatment of Malignant Tumors†

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Application of Zwitterionic Polymers in the Treatment of Malignant Tumors^†