高等学校化学学报 ›› 2019, Vol. 40 ›› Issue (1): 76-82.doi: 10.7503/cjcu20180448

• 有机化学 • 上一篇    下一篇

八元瓜环对氯化矢车菊素溶解性、稳定性及抗氧化性的影响

蒋静1, 黄亚励2, 张奇龙2(), 徐红2(), 孙晓红3   

  1. 1. 贵州医科大学环境污染与疾病监控教育部重点实验室, 2. 基础医学院, 3.食品安全学院, 贵阳 550025
  • 收稿日期:2018-06-20 出版日期:2019-01-10 发布日期:2018-12-18
  • 作者简介:

    联系人简介: 张奇龙, 男, 教授, 主要从事功能性配合物和光谱分析方面的研究. E-mail: gzuqlzhang@126.com;徐 红, 女, 教授, 主要从事光谱分析方面的研究. E-mail: 1738943269@qq.com

  • 基金资助:
    贵州省区域内一流学科建设项目-公共卫生与预防医学(批准号: 黔教科研发2017[85]号)、 贵州省科技计划课题(批准号: 黔科合LH字[2015]7346)、 贵阳市科技计划项目(批准号: 筑科合同[2016001]001号)和贵州省苗医药重点实验室开放课题基金(批准号: 黔苗医药K字[2017]023)资助.

Effects of Cucurbit[8]uril on the Solubility, Stability and Antioxidation of Cyanidin

JIANG Jing1, HUANG Yali2, ZHANG Qilong2,*(), XU Hong2,*(), SUN Xiaohong3   

  1. 1. Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, 2. School of Basic Medical Sciences, 3. School of Food Safety, Guizhou Medical University, Guiyang 550025, China
  • Received:2018-06-20 Online:2019-01-10 Published:2018-12-18
  • Contact: ZHANG Qilong,XU Hong E-mail:gzuqlzhang@126.com;1738943269@qq.com
  • Supported by:
    † Supported by the First-Class Discipline Construction Project of Guizhou Province-Public Health and Preventive Medicine, China(No.2017[85]), the Science and Technology Program Project of Guizhou Province, China(No.[2015]7346), the Science and Technology Foundation of Guiyang, China(No.[20161001]001) and the Open Project Fund of Guizhou Provincial Miao Medicine Key Laboratory, China(No.[2017]023).

摘要:

采用核磁共振氢谱(1H NMR)、 红外光谱及紫外吸收光谱等方法考察了八元瓜环(Q[8])对氯化矢车菊素(Cy)的包结作用. 结果表明, 在pH=0.8的盐酸介质中, Q[8]可与Cy形成摩尔比为1:1的主客体配合物, 紫外吸收光谱法测得的主-客体结合常数为1.51×106 . 相溶解度研究结果表明, Q[8]能使饱和Cy溶液的溶解度增大, 当Q[8]浓度为100 μmol/L时, 可使Cy的溶解度增大12.21倍. 紫外吸收光谱随时间变化结果表明, 在较为稳定存在形态及相同实验条件下, Q[8]/Cy溶液比Cy溶液的稳定性提高了2.58倍. 抗氧化性实验结果表明, Q[8]/Cy包合物和Cy均表现出较好的抗氧化活性.

关键词: 八元瓜环, 氯化矢车菊素, 溶解性, 稳定性, 抗氧化性

Abstract:

The inclusion of cucurbit[8]uril(Q[8]) with cyanidin(Cy) was investigated and charactrized by means of nuclear magnetic resonance spectrometer, infrared spectroscopy and UV-visible spectrophotometer absorption spectroscopy. The results showed that Q[8] and Cy could form a 1:1 host-guest complex in acid aqueous medium and the host-guest binding constant was determined to be 1.51×106. Phase solubility study results suggested that Q[8] could increase the solubility of saturated Cy solution up to 12.21 times, and the results of time-dependent UV-Vis absorption spectra indicated that the stability of Q[8]/Cy solution was 2.58 times higher than that of Cy solution in the same experimental conditions. The results of anti-oxidation experiments showed that both Q[8]/Cy inclusion compound and Cy showed good antioxidant activity.

Key words: Cucurbit[8]uril, Cyanidin, Solubility, Stability, Antioxidation

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