高等学校化学学报 ›› 2020, Vol. 41 ›› Issue (5): 909-923.doi: 10.7503/cjcu20190646

• 庆祝《高等学校化学学报》复刊40周年专栏 • 上一篇    下一篇

聚合物纳米药物载体的研究进展

赵宇1,曹琬晴1,2,刘阳1,2,*()   

  1. 1. 南开大学化学学院, 功能高分子材料教育部重点实验室
    2. 化学国家级教学示范中心(南开大学), 天津 300071
  • 收稿日期:2019-12-10 出版日期:2020-05-10 发布日期:2020-02-24
  • 通讯作者: 刘阳 E-mail:yliu@nankai.edu.cn
  • 基金资助:
    国家重点研发计划“纳米科技”项目(2018YFA0209700)

Recent Advances in Polymeric Nano-sized Carrier Systems

ZHAO Yu1,CAO Wanqing1,2,LIU Yang1,2,*()   

  1. 1. Key Laboratory of Functional Polymer Materials of Ministry of Education,College of Chemistry, Nankai University, Tianjin 300071, China
    2. National Chemical Experimental Teaching Demonstration Center(Nankai University), Tianjin 300071, China
  • Received:2019-12-10 Online:2020-05-10 Published:2020-02-24
  • Contact: Yang LIU E-mail:yliu@nankai.edu.cn
  • Supported by:
    † Supported by the National Key Research and Development Programs of China(Nanotechnology)(2018YFA0209700)

摘要:

近年来, 大量研究结果表明纳米技术可显著提高传统药物的疾病治疗效果, 并在生物医学领域引起了广泛关注. 迄今, 多种聚合物纳米体系已被研发并用于药物的靶向递送. 随着纳米技术的不断发展, 各类生物微环境响应的功能基团也被应用于构筑新型药物载体, 以提高患病部位的药物富集及减少药物的毒副作用. 聚合物纳米药物载体在癌症治疗、 代谢类疾病治疗及抗菌等方面展现出巨大潜力. 本文系统评述了聚合物纳米药物载体的最新研究进展及在生物医药方面的应用.

关键词: 纳米技术, 聚合物, 纳米药物载体, 靶向药物递送, 药物控释

Abstract:

In recent years, the nanotechnology has attracted a lot of attention in biomedicine owing to the great enhancement of therapeutic efficiency. A variety of polymeric nano-sized carrier systems have been deve-loped for targeted drug delivery and drug controlled release. In order to improve drug accumulation in the focal lesions and reduce the side effects, smart stimuli-responsive nano-sized carriers have emerged. Now, the polymeric nano-sized drug carriers have shown great potential for cancers, metabolic disorders and infectious diseases. This review focuses on the recent advances in polymeric nano-sized carriers and their applications in biomedicine.

Key words: Nanotechnology, Polymer, Nano-sized carrier system, Targeted drug delivery, Drug controlled release

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