聚合物纳米药物载体的研究进展

doi:10.7503/cjcu20190646

摘要/Abstract

摘要：

近年来, 大量研究结果表明纳米技术可显著提高传统药物的疾病治疗效果, 并在生物医学领域引起了广泛关注. 迄今, 多种聚合物纳米体系已被研发并用于药物的靶向递送. 随着纳米技术的不断发展, 各类生物微环境响应的功能基团也被应用于构筑新型药物载体, 以提高患病部位的药物富集及减少药物的毒副作用. 聚合物纳米药物载体在癌症治疗、代谢类疾病治疗及抗菌等方面展现出巨大潜力. 本文系统评述了聚合物纳米药物载体的最新研究进展及在生物医药方面的应用.

关键词: 纳米技术, 聚合物, 纳米药物载体, 靶向药物递送, 药物控释

Abstract:

In recent years, the nanotechnology has attracted a lot of attention in biomedicine owing to the great enhancement of therapeutic efficiency. A variety of polymeric nano-sized carrier systems have been deve-loped for targeted drug delivery and drug controlled release. In order to improve drug accumulation in the focal lesions and reduce the side effects, smart stimuli-responsive nano-sized carriers have emerged. Now, the polymeric nano-sized drug carriers have shown great potential for cancers, metabolic disorders and infectious diseases. This review focuses on the recent advances in polymeric nano-sized carriers and their applications in biomedicine.

Key words: Nanotechnology, Polymer, Nano-sized carrier system, Targeted drug delivery, Drug controlled release

中图分类号:

O633

赵宇, 曹琬晴, 刘阳. 聚合物纳米药物载体的研究进展[J]. 高等学校化学学报, 2020, 41(5): 909-923.

ZHAO Yu, CAO Wanqing, LIU Yang. Recent Advances in Polymeric Nano-sized Carrier Systems ^†[J]. Chemical Journal of Chinese Universities, 2020, 41(5): 909-923.

图/表 11

参考文献 91

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Drug	Material	Stimuli-responsive condition	Application	Ref.
Doxorubicin	PEG-b-P(Lys/CA-DOX), PAE-b-P(Lys/CA-DOX)	pH	Cancer	[15]
Doxorubicin	DNA	pH	Cancer	[41]
Doxorubicin	PEG-b-PEYM	pH	Cancer	[38]
Doxorubicin	PLLA-PEG	pH	Cancer	[69]
Doxorubicin	PVA,m-dextran	pH	Cancer	[37]
Doxorubicin	PETMP-AU-PEG	pH	Cancer	[43]
Factor-related apoptosis-inducing ligand and Doxorubicin	m-HA	pH	Cancer	[47]
miRNA	AAm and APm	pH	Cancer	[10]
Doxorubicin, Loperamide	PLGA	pH	Cancer, central analgesic effects	[20]
Methotrexate	Chitosan	pH	Central nervous systems malignancies	[28]
Salvianolic acid B, tanshinone IIA and panax notoginsenoside	PLGA	pH	Cerebral ischemia reperfusion(I/R) injury	[19]
Doxorubicin	Gelatin and polydopamine	pH, enzyme, NIR	Cancer	[30]
Doxorubicin/indocyanine green	PLGA	NIR	Cancer	[68]
Levofloxacin	PVA/SA	UV	Antibiosis	[67]
Curcumin	PEG-pLys	ROS	Alzheimer’s disease	[16]
DNA	Poly(amino thioketal)	ROS	Cancer	[59]
Gemcitabine and anti-PD-L1	PVA-TSPBA	ROS	Cancer	[29]
siRNA	PEG-b-P(Gu/Hb)/Ang-PEG-b-PGu	ROS	Cancer	[60]
MTO	PEG-PolyMTO	ROS	Cancer	[61]
Doxorubicin	poly(ether-urethane)	GSH	Cancer	[53]
Lira	PCGA-PEG-PCGA	Heat	Diabetes	[70]
Doxorubicin	PAMAM	Radiation	Cancer	[26]
Monoclonal Antibodies	2-methacryloyloxyethyl phosphorylcholine	Enzyme	Cancer	[48]
Vancomycin	PEG-b-PP and PEG-b-PC	Enzyme	Antibiosis	[71]
Insulin	Chitosan/alginate and m-dextran	Glucose	Diabetes	[36]
Insulin	PEG-b-(PAA-co-PAAPBA)	Glucose	Diabetes	[72]
Insulin	P(NIPAM-Dex-PBA)	Glucose	Diabetes	[73]
KLVFF	PCL-b-PAE,PCL-b-PEG	—	Alzheimer’s disease	[74]
KLVFF and Beclin-1	PEG	—	Alzheimer’s disease	[75]
Docetaxel	PEG-DMPE, DMPC,DHPC	—	Cancer	[14]
Rivastigmine	Poly(n-butylcyanoacrylate)	—	Alzheimer’s disease	[76]
p53 protein	AAm and N-azidodeca(ethylene glycol)ethylacrylamide	—	Cancer	[52]
Ciprofloxacin	PEG-b-cholesterol	—	Antibiosis	[13]
Ciprofloxacin	PLGA	—	Antibiosis	[77]

Drug	Material	Stimuli-responsive condition	Application	Ref.
Doxorubicin	PEG-b-P(Lys/CA-DOX), PAE-b-P(Lys/CA-DOX)	pH	Cancer	[15]
Doxorubicin	DNA	pH	Cancer	[41]
Doxorubicin	PEG-b-PEYM	pH	Cancer	[38]
Doxorubicin	PLLA-PEG	pH	Cancer	[69]
Doxorubicin	PVA,m-dextran	pH	Cancer	[37]
Doxorubicin	PETMP-AU-PEG	pH	Cancer	[43]
Factor-related apoptosis-inducing ligand and Doxorubicin	m-HA	pH	Cancer	[47]
miRNA	AAm and APm	pH	Cancer	[10]
Doxorubicin, Loperamide	PLGA	pH	Cancer, central analgesic effects	[20]
Methotrexate	Chitosan	pH	Central nervous systems malignancies	[28]
Salvianolic acid B, tanshinone IIA and panax notoginsenoside	PLGA	pH	Cerebral ischemia reperfusion(I/R) injury	[19]
Doxorubicin	Gelatin and polydopamine	pH, enzyme, NIR	Cancer	[30]
Doxorubicin/indocyanine green	PLGA	NIR	Cancer	[68]
Levofloxacin	PVA/SA	UV	Antibiosis	[67]
Curcumin	PEG-pLys	ROS	Alzheimer’s disease	[16]
DNA	Poly(amino thioketal)	ROS	Cancer	[59]
Gemcitabine and anti-PD-L1	PVA-TSPBA	ROS	Cancer	[29]
siRNA	PEG-b-P(Gu/Hb)/Ang-PEG-b-PGu	ROS	Cancer	[60]
MTO	PEG-PolyMTO	ROS	Cancer	[61]
Doxorubicin	poly(ether-urethane)	GSH	Cancer	[53]
Lira	PCGA-PEG-PCGA	Heat	Diabetes	[70]
Doxorubicin	PAMAM	Radiation	Cancer	[26]
Monoclonal Antibodies	2-methacryloyloxyethyl phosphorylcholine	Enzyme	Cancer	[48]
Vancomycin	PEG-b-PP and PEG-b-PC	Enzyme	Antibiosis	[71]
Insulin	Chitosan/alginate and m-dextran	Glucose	Diabetes	[36]
Insulin	PEG-b-(PAA-co-PAAPBA)	Glucose	Diabetes	[72]
Insulin	P(NIPAM-Dex-PBA)	Glucose	Diabetes	[73]
KLVFF	PCL-b-PAE,PCL-b-PEG	—	Alzheimer’s disease	[74]
KLVFF and Beclin-1	PEG	—	Alzheimer’s disease	[75]
Docetaxel	PEG-DMPE, DMPC,DHPC	—	Cancer	[14]
Rivastigmine	Poly(n-butylcyanoacrylate)	—	Alzheimer’s disease	[76]
p53 protein	AAm and N-azidodeca(ethylene glycol)ethylacrylamide	—	Cancer	[52]
Ciprofloxacin	PEG-b-cholesterol	—	Antibiosis	[13]
Ciprofloxacin	PLGA	—	Antibiosis	[77]