高等学校化学学报 ›› 2020, Vol. 41 ›› Issue (5): 909.doi: 10.7503/cjcu20190646
• 庆祝《高等学校化学学报》复刊40周年专栏 • 上一篇 下一篇
收稿日期:
2019-12-10
出版日期:
2020-05-10
发布日期:
2020-02-24
通讯作者:
刘阳
E-mail:yliu@nankai.edu.cn
基金资助:
ZHAO Yu1,CAO Wanqing1,2,LIU Yang1,2,*()
Received:
2019-12-10
Online:
2020-05-10
Published:
2020-02-24
Contact:
Yang LIU
E-mail:yliu@nankai.edu.cn
Supported by:
摘要:
近年来, 大量研究结果表明纳米技术可显著提高传统药物的疾病治疗效果, 并在生物医学领域引起了广泛关注. 迄今, 多种聚合物纳米体系已被研发并用于药物的靶向递送. 随着纳米技术的不断发展, 各类生物微环境响应的功能基团也被应用于构筑新型药物载体, 以提高患病部位的药物富集及减少药物的毒副作用. 聚合物纳米药物载体在癌症治疗、 代谢类疾病治疗及抗菌等方面展现出巨大潜力. 本文系统评述了聚合物纳米药物载体的最新研究进展及在生物医药方面的应用.
中图分类号:
TrendMD:
赵宇, 曹琬晴, 刘阳. 聚合物纳米药物载体的研究进展. 高等学校化学学报, 2020, 41(5): 909.
ZHAO Yu, CAO Wanqing, LIU Yang. Recent Advances in Polymeric Nano-sized Carrier Systems . Chem. J. Chinese Universities, 2020, 41(5): 909.
Fig.3 Selected examples of PEG-containing block polymers which can be self-assembled to form polymeric micelles for drug delivery(A) and the representative structure of polymeric micelles(B)[12] Copyright 2018, The Royal Society of Chemistry.
Fig.7 Cocoon-like DNA nanoclew integrated with an acid-sensitive nanocapsule encapsulating DNase Ⅰ for controlled intracellular release of DOX[41](A) and scheme illustration showing the preparation of the tumor pH-labile linkage-bridged block copolymer PEG5K-Dlinkm-PLGA11K(B)[42] (A) Copyright 2014, American Chemical Society; (B) copyright 2016, Elsevier.
Fig.9 Cationic polyplex containing thioketal linkages for ROS-activated intracellular DNA release(A)[59] and illustration of the formation of “triple-interaction”-stabilized siRNA nanomedicine and ROS responsiveness, active targeting, and combinational RNAi therapy in glioblastoma(B)[60] (A) Copyright 2013, Wiley Online Library; (B) Copyright 2019, Wiley Online Library.
Fig.10 Schematic design of the photo-cleavable polyprodrug(LHP)-loaded polyvinyl alcohol/sodium alginate(PVA/SA) wound dressing and its UV-responsive antibacterial property[67] Copyright 2017, the Royal Society of Chemistry.
Drug | Material | Stimuli-responsive condition | Application | Ref. | |||
---|---|---|---|---|---|---|---|
Doxorubicin | PEG-b-P(Lys/CA-DOX), PAE-b-P(Lys/CA-DOX) | pH | Cancer | [ | |||
Doxorubicin | DNA | pH | Cancer | [ | |||
Doxorubicin | PEG-b-PEYM | pH | Cancer | [ | |||
Doxorubicin | PLLA-PEG | pH | Cancer | [ | |||
Doxorubicin | PVA,m-dextran | pH | Cancer | [ | |||
Doxorubicin | PETMP-AU-PEG | pH | Cancer | [ | |||
Factor-related apoptosis-inducing ligand and Doxorubicin | m-HA | pH | Cancer | [ | |||
miRNA | AAm and APm | pH | Cancer | [ | |||
Doxorubicin, Loperamide | PLGA | pH | Cancer, central analgesic effects | [ | |||
Methotrexate | Chitosan | pH | Central nervous systems malignancies | [ | |||
Salvianolic acid B, tanshinone IIA and panax notoginsenoside | PLGA | pH | Cerebral ischemia reperfusion(I/R) injury | [ | |||
Doxorubicin | Gelatin and polydopamine | pH, enzyme, NIR | Cancer | [ | |||
Doxorubicin/indocyanine green | PLGA | NIR | Cancer | [ | |||
Levofloxacin | PVA/SA | UV | Antibiosis | [ | |||
Curcumin | PEG-pLys | ROS | Alzheimer’s disease | [ | |||
DNA | Poly(amino thioketal) | ROS | Cancer | [ | |||
Gemcitabine and anti-PD-L1 | PVA-TSPBA | ROS | Cancer | [ | |||
siRNA | PEG-b-P(Gu/Hb)/Ang-PEG-b-PGu | ROS | Cancer | [ | |||
MTO | PEG-PolyMTO | ROS | Cancer | [ | |||
Doxorubicin | poly(ether-urethane) | GSH | Cancer | [ | |||
Lira | PCGA-PEG-PCGA | Heat | Diabetes | [ | |||
Doxorubicin | PAMAM | Radiation | Cancer | [ | |||
Monoclonal Antibodies | 2-methacryloyloxyethyl phosphorylcholine | Enzyme | Cancer | [ | |||
Vancomycin | PEG-b-PP and PEG-b-PC | Enzyme | Antibiosis | [ | |||
Insulin | Chitosan/alginate and m-dextran | Glucose | Diabetes | [ | |||
Insulin | PEG-b-(PAA-co-PAAPBA) | Glucose | Diabetes | [ | |||
Insulin | P(NIPAM-Dex-PBA) | Glucose | Diabetes | [ | |||
KLVFF | PCL-b-PAE,PCL-b-PEG | — | Alzheimer’s disease | [ | |||
KLVFF and Beclin-1 | PEG | — | Alzheimer’s disease | [ | |||
Docetaxel | PEG-DMPE, DMPC,DHPC | — | Cancer | [ | |||
Rivastigmine | Poly(n-butylcyanoacrylate) | — | Alzheimer’s disease | [ | |||
p53 protein | AAm and N-azidodeca(ethylene glycol)ethylacrylamide | — | Cancer | [ | |||
Ciprofloxacin | PEG-b-cholesterol | — | Antibiosis | [ | |||
Ciprofloxacin | PLGA | — | Antibiosis | [ |
Table 1 Recent advances in polymeric nano-sized carrier systems
Drug | Material | Stimuli-responsive condition | Application | Ref. | |||
---|---|---|---|---|---|---|---|
Doxorubicin | PEG-b-P(Lys/CA-DOX), PAE-b-P(Lys/CA-DOX) | pH | Cancer | [ | |||
Doxorubicin | DNA | pH | Cancer | [ | |||
Doxorubicin | PEG-b-PEYM | pH | Cancer | [ | |||
Doxorubicin | PLLA-PEG | pH | Cancer | [ | |||
Doxorubicin | PVA,m-dextran | pH | Cancer | [ | |||
Doxorubicin | PETMP-AU-PEG | pH | Cancer | [ | |||
Factor-related apoptosis-inducing ligand and Doxorubicin | m-HA | pH | Cancer | [ | |||
miRNA | AAm and APm | pH | Cancer | [ | |||
Doxorubicin, Loperamide | PLGA | pH | Cancer, central analgesic effects | [ | |||
Methotrexate | Chitosan | pH | Central nervous systems malignancies | [ | |||
Salvianolic acid B, tanshinone IIA and panax notoginsenoside | PLGA | pH | Cerebral ischemia reperfusion(I/R) injury | [ | |||
Doxorubicin | Gelatin and polydopamine | pH, enzyme, NIR | Cancer | [ | |||
Doxorubicin/indocyanine green | PLGA | NIR | Cancer | [ | |||
Levofloxacin | PVA/SA | UV | Antibiosis | [ | |||
Curcumin | PEG-pLys | ROS | Alzheimer’s disease | [ | |||
DNA | Poly(amino thioketal) | ROS | Cancer | [ | |||
Gemcitabine and anti-PD-L1 | PVA-TSPBA | ROS | Cancer | [ | |||
siRNA | PEG-b-P(Gu/Hb)/Ang-PEG-b-PGu | ROS | Cancer | [ | |||
MTO | PEG-PolyMTO | ROS | Cancer | [ | |||
Doxorubicin | poly(ether-urethane) | GSH | Cancer | [ | |||
Lira | PCGA-PEG-PCGA | Heat | Diabetes | [ | |||
Doxorubicin | PAMAM | Radiation | Cancer | [ | |||
Monoclonal Antibodies | 2-methacryloyloxyethyl phosphorylcholine | Enzyme | Cancer | [ | |||
Vancomycin | PEG-b-PP and PEG-b-PC | Enzyme | Antibiosis | [ | |||
Insulin | Chitosan/alginate and m-dextran | Glucose | Diabetes | [ | |||
Insulin | PEG-b-(PAA-co-PAAPBA) | Glucose | Diabetes | [ | |||
Insulin | P(NIPAM-Dex-PBA) | Glucose | Diabetes | [ | |||
KLVFF | PCL-b-PAE,PCL-b-PEG | — | Alzheimer’s disease | [ | |||
KLVFF and Beclin-1 | PEG | — | Alzheimer’s disease | [ | |||
Docetaxel | PEG-DMPE, DMPC,DHPC | — | Cancer | [ | |||
Rivastigmine | Poly(n-butylcyanoacrylate) | — | Alzheimer’s disease | [ | |||
p53 protein | AAm and N-azidodeca(ethylene glycol)ethylacrylamide | — | Cancer | [ | |||
Ciprofloxacin | PEG-b-cholesterol | — | Antibiosis | [ | |||
Ciprofloxacin | PLGA | — | Antibiosis | [ |
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