高等学校化学学报

高等学校化学学报

• 研究论文 • 上一篇    下一篇

含腺嘌呤的杯芳烃衍生物的合成、表征及其对核苷碱基的分子识别性质

张海燕2, 史慧杰1, 施宪法1   

    1. 同济大学化学系, 上海 200092;
    2. 石河子大学化学化工学院, 石河子 832003
  • 收稿日期:2007-12-26 修回日期:1900-01-01 出版日期:2008-09-10 发布日期:2008-09-10
  • 通讯作者: 施宪法

Synthesis and Characterization of p-tert-Butylcalixarene Derivative Containing Adenine and Its Molecular Recognition to Nucleotides and Bases

ZHANG Hai-Yan2, SHI Hui-Jie1, SHI Xian-Fa1*   

    1. Department of Chemistry, Tongji University, Shanghai 200092, China;
    2. College of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832003, China
  • Received:2007-12-26 Revised:1900-01-01 Online:2008-09-10 Published:2008-09-10
  • Contact: SHI Xian-Fa

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被引次数

7

摘要： 设计合成了一种新型含腺嘌呤基的杯芳烃衍生物(AC)5,11,17,23-四叔丁基-25, 27-二羟基-26-[1-(9-腺嘌呤)-丙氧基]-28-溴丙氧基杯芳烃, 通过红外光谱、元素分析、核磁共振谱和电喷雾质谱等手段对其进行了表征,确认为目标产物; 并采用紫外分光光度法研究了AC的分子识别作用, 通过测定AC与不同浓度、不同组分的核苷、碱基混合体系的吸光度, 证明了AC对尿嘧啶、尿苷具有分子识别作用, 能从其它核苷或碱基共存的体系中将尿苷或尿嘧啶识别出来.

关键词: 杯芳烃衍生物, 腺嘌呤, 分子识别, 紫外分光光度法

Abstract: A new adenine-containing derivative of p-tert-butylcalixarene(AC)5,11,17,23-tetra-t-butyl-25,27-bihydroxy-26-(1-(9-adenineyl)-propoxy)-28-bromopropoxycalixarene was synthesized and characterized via IR, EA, 1H NMR and ESI-MS spectra. The molecular recognition of AC to different nucleotides and bases was studied via UV-Vis method: the absorbance of mixed systems with different concentrations or components was measured. The results show that AC can selectively bond with uracil and uridine from other nucleotides and bases, which means AC can recognize uracil and uridine.

Key words: Calixarene derivative, Adenine, Molecular recognition, UV-Vis spectrum

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