高等学校化学学报

高等学校化学学报

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超顺磁/荧光双功能纳米粒子的合成、表征和生物功能化

谭芳1, 庄峙厦1,2, 杨黄浩2, 陈成祥1, 王小如1,2   

    1. 厦门大学化学化工学院化学系, 现代分析科学教育部重点实验室, 厦门 361005;
    2. 国家海洋局第一海洋研究所, 青岛 266061
  • 收稿日期:2006-12-01 修回日期:1900-01-01 出版日期:2007-08-10 发布日期:2007-08-10
  • 通讯作者: 庄峙厦

Synthesis, Characterization and Biological Functionalization of Superparamagnetic/Fluorescent Bifunctional Nanoparticles

TAN Fang1, ZHUANG Zhi-Xia1,2*, YANG Huang-Hao2, CHEN Cheng-Xiang1, WANG Xiao-Ru1,2   

    1. The Key Laboratory of Analytical Sciences of MOE, Department of Chemistry, Xiamen University, Xiamen 361005, China;
    2. The First Institute of Oceanography, SOA, Qingdao 266061, China
  • Received:2006-12-01 Revised:1900-01-01 Online:2007-08-10 Published:2007-08-10
  • Contact: ZHUANG Zhi-Xia

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被引次数

11

摘要： 通过反相微乳液聚合, 在热解法合成的MnFe2O4纳米粒子表面修饰了一层掺杂有荧光染料(联吡啶钌)的SiO2, 制备了同时具有超顺磁性和荧光特性的双功能纳米粒子. 再通过氨基硅烷的修饰作用, 将该双功能纳米粒子与万古霉素结合, 所得到的生物功能化的纳米粒子表现出很好的对大肠杆菌的识别和磁性分离能力. 本研究制备的超顺磁/荧光双功能纳米粒子具有磁性强、光稳定性高、制备简单、分散性好和尺寸均匀等优点, 可以推断这种新型纳米粒子在生物学、医学和分析化学等领域中将有广阔的应用前景.

关键词: 超顺磁, 荧光, 纳米粒子, 生物功能化

Abstract: A novel class of fluorescent/superparamagnetic bifunctional nanoparticles was synthesized via the reverse microemulsion technique. These nanoparticles were studied with transmission electron microscopy(TEM) and SQUID microscopy. The results show that these nanoparticles have a typical diameter of 40 nm and a saturated magnetic moment of 1.9 emu/g at room temperature. The experiment results also show that these nanoparticles exhibit a strong excitonic photoluminescence. Then, these bifunctional nanoparticles were modified with vancomycin for binding. The results show that these vancomycin modified nanoparticles can capture selectively bacterias.

Key words: Superparamagnetics, Fluorescence, Nanoparticle, Biological functionalization

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