高等学校化学学报

高等学校化学学报 ›› 2005, Vol. 26 ›› Issue (6): 1086.

• 研究论文 • 上一篇    下一篇

二联苯和氨基酸构建的大环化合物自组装研究

郭炜1,2, 米学玲1, 王璟1, 何家骐1, 程津培1   

  1. 1. 南开大学化学系, 天津300071;
    2. 山西大学化学化工学院, 太原030006
  • 收稿日期:2004-07-02 出版日期:2005-06-10 发布日期:2005-06-10
  • 通讯作者: 程津培(1948年出生),男,教授,博士生导师,中国科学院院士,主要从事物理有机化学研究.E-mail:jpcheng@nankai.edu.cn E-mail:jpcheng@nankai.edu.cn
  • 基金资助:

    国家自然科学基金(批准号:20072020和29832041);国家重点基础研究发展计划(批准号:G2000078100)资助.

Self-assembly of Biphenyl-bridged and Amino Acid-based Macrocycle Compounds

GUO Wei1,2, MI Xue-Ling1, WANG Jing1, HE Jia-Qi1, CHENG Jin-Pei1   

  1. 1. Department of Chemistry, Nankai University, Tianjin 300071, China;
    2. College of Chemistry and Chemical Engeneering, Shanxi University, Taiyuan 030006, China
  • Received:2004-07-02 Online:2005-06-10 Published:2005-06-10

PDF (PC)

被引次数

11

摘要： 以二联苯作为模板,设计并合成了3个二联苯和氨基酸构建的大环化合物.晶体结构结果研究发现,在固态,这些大环化合物分别组装成了管状、三维网状和链状的超分子结构,其中,C—H…O氢键在维持这些大环的组装方面发挥了重要作用.这将有助于进一步增加对分子自组装、分子识别以及生物大分子的稳定性方面的理解.

关键词: 大环化合物, 二联苯, 氨基酸, 自组装, C&mdash, H&hellip, O氢键

Abstract: As part of our efforts aimed at developing molecular receptors and peptide conformational templates, we have conducted a research on design, synthesis, and application of structurally modified cyclopeptides. In this paper, we disigned and synthesized three biphenyl-bridged, amino acid-based macrocycles. The investigation of crystallograghic structures reveals that in the solid state, these macrocycles were assembled into twin-tube, 3D network and chain-like supramolecular structures, respectively, in which the C-H...O hydrogen-bonds play important roles. These findings may be helpful for understanding the role of the C-H...O hydrogen bonding in determining crystal packing, molecular recognition, and the structural stability of biological macromolecules.

Key words: Macrocycle compound, Biphenyl, Amino acid, Self-assembly, C-H...O hydrogen bond

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