高等学校化学学报 ›› 2020, Vol. 41 ›› Issue (6): 1163-1173.doi: 10.7503/cjcu20190667

• 庆祝《高等学校化学学报》复刊40周年专栏 • 上一篇    下一篇

弹性肽在超分子组装中的应用

侯春喜*(),李逸佳,王婷婷,刘盛达,闫腾飞,刘俊秋*()   

  1. 吉林大学超分子结构与材料国家重点实验室, 化学学院, 长春 130012
  • 收稿日期:2019-12-14 出版日期:2020-06-10 发布日期:2020-04-09
  • 通讯作者: 侯春喜,刘俊秋 E-mail:chunxihou@jlu.edu.cn;junqiuliu@jlu.edu.cn
  • 基金资助:
    国家重点研发计划项目(2018YFA0901600);吉林省科技发展计划项目(20180101198JC)

Application of Elastin-like Polypeptides in Supramolecular Assembly

HOU Chunxi*(),LI Yijia,WANG Tingting,LIU Shengda,YAN Tengfei,LIU Junqiu*()   

  1. State Key laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, China
  • Received:2019-12-14 Online:2020-06-10 Published:2020-04-09
  • Contact: Chunxi HOU,Junqiu LIU E-mail:chunxihou@jlu.edu.cn;junqiuliu@jlu.edu.cn
  • Supported by:
    † Project of National Key Research and Development, China(2018YFA0901600);Project of Science and Technology Development Plan of Jilin Province, China(20180101198JC)

摘要:

系统总结了弹性肽(ELPs)的自组装及其组装体的生物应用研究现状, 讨论了ELPs的温控相变在构建超分子组装体方面的独特优势, 探讨了ELPs纳米结构的序列敏感性, 展望了ELPs在超分子组装中的实际应用.

关键词: 弹性肽, 自组装, 纳米结构, 温度响应, 药物传递

Abstract:

Recent research progress of elastin-like polypeptides(ELPs) in temperature-responsive supramolecular structures is summarized systematically. The unique advantages of temperature controlled phase transition of elastin in the construction of supramolecular assembly are discussed and the sequence sensitivity of ELPs nanostructures is also demonstrated. Finally, the application of ELPs in supramolecular assembly in the future is prospected.

Key words: Elastin-like peptides(ELPs), Self-assembly, Nanostructure, Temperature-responsive, Drug delivery

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