高等学校化学学报

高等学校化学学报 ›› 2005, Vol. 26 ›› Issue (2): 373.

• 研究快报 • 上一篇    下一篇

一种新型的可生物降解的热敏凝胶微粒的制备

朱文, 张颖, 王标兵, 丁建东   

  1. 复旦大学高分子科学系, 聚合物分子工程教育部重点实验室, 上海 200433
  • 收稿日期:2004-10-26 出版日期:2005-02-10 发布日期:2005-02-10
  • 通讯作者: 丁建东(1965年出生),男,教授,博士生导师,主要从事生物医用高分子材料、组织工程、药物缓释载体和蛋白质研究.E-mail:jdding1@fudan.edu.cn E-mail:jdding1@fudan.edu.cn
  • 基金资助:

    国家“八六三”计划项目(批准号:2004AA215170);国家自然科学基金(批准号:20174006,20221402,20374015,30271293);高等学校青年教师教学和科研奖励基金;上海市科技发展基金;国家重点基础研究“九七三”项目(批准号:G1999054306-03).

Preparation of a Novel Thermosensitive and Biodegradable Microgel Particles

ZHU Wen, ZHANG Ying, WANG Biao-Bing, DING Jian-Dong   

  1. Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, China
  • Received:2004-10-26 Online:2005-02-10 Published:2005-02-10

PDF (PC)

被引次数

10

关键词: 水凝胶, 热敏性, 可降解, 微粒, 大分子单体

Abstract: A novel biodegradable and thermosensitive microgel particle was prepared via suspension polymerization of a well-designed biodegradable macromonomer. The macromonomer is composed of amphiphilic block copolymer PEO-PPO-PEO, oligo(ester) and acryloyl end groups. Ammonium persulfate was employed as the initiator and N,N,N',N'-tetramethylethylene-diamine as the accelerator. The resultant hydrogel particles were confirmed to be reversely thermosensitive as well as biodegradable.

Key words: Hydrogel, Thermosensitive, Biodegradability, Microparticle, Macromonomer

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