吗啉胍同多十钒酸盐的自组装合成、结构表征及抗菌活性

高等学校化学学报 ›› 2004, Vol. 25 ›› Issue (6): 997.

吗啉胍同多十钒酸盐的自组装合成、结构表征及抗菌活性

刘术侠¹, 翟宏菊^1,2, 彭军¹, 李德慧¹, 戴知旻¹, 王恩波¹, 胡宁海³, 贾恒庆³

1. 东北师范大学化学学院, 长春 130024;
2. 吉林师范大学化学学院, 四平 136000;
3. 中国科学院长春应用化学研究所, 长春 130022

收稿日期:2003-08-12 出版日期:2004-06-24 发布日期:2004-06-24
通讯作者: 刘术侠(1964年出生),女,博士,副教授,主要从事新型多金属氧酸盐的合成及药物活性研究.E-mail:liusx@nenu.edu.cn E-mail:liusx@nenu.edu.cn
基金资助:
国家自然科学基金(批准号:20071008);东北师范大学校内基金(批准号:111433000)资助

Self-assembly Synthesis,Structure Characterization and Antibacterial Activity of Complexes （ABOB）₄[H₂V₁₀O₂₈]·9H₂O and （ABOB）₆[V₁₀O₂₈] ·4H₂O（ABOB=Moroxydine）

LIU Shu-Xia¹, ZHAI Hong-Ju^1,2, PENG Jun¹, LI De-Hui¹, DAI Zhi-Min¹, WANG En-Bo¹, HU Ning-Hai³, JIA Heng-Qing³

1. Faculty of Chemistry, Northeast Normal University, Changchun 130024, China;
2. College of Chemistry, Jilin Normal University, Siping 136000, China;
3. Changchun Institute of Applied Chemistry, Chinese Academic of Sciences, Changchun 130022, China

Received:2003-08-12 Online:2004-06-24 Published:2004-06-24

摘要/Abstract

摘要： 通过十钒酸盐与吗啉胍在不同pH值水溶液中的自组装,合成了2个新化合物(C₆H₁₄N₅O)₄·[H₂V₁₀O₂₈]·9H₂O(1)和(C₆H₁₄N₅O)₆[V₁₀O₂₈]·4H₂O(2).通过IR,⁵¹VNMR和X射线衍射等方法对其结构进行了表征.结果表明,化合物1和2是通过十钒酸根阴离子与质子化的吗啉胍阳离子以静电力和氢键构筑的,多阴离子及吗啉胍的结构基本保持不变.抗菌试验结果表明,两种化合物对金黄色葡萄球菌、表皮葡萄球菌、耐甲氧西林金黄葡萄球菌和耐甲氧西林表皮葡萄球菌均具有较强的抑制活性.

关键词: 十钒酸盐, 吗啉胍, 自组装, 合成, 抗菌活性

Abstract: Two novel complexes（C₆H₁₄ N₅O）₄ [H₂V₁₀ O₂₈ ] ·9H₂O（1） and （C₆H₁₄ N₅O）₆ [V₁₀ O₂₈ ] ·4H₂O（2） were synthesized by the self-assembly of decavanadate and ABOB in aqueous medium at different pH values for the first time. Their structures were determined by means of IR, ⁵¹V NMR and X-ray diffraction. Complex 1 crystallizes in the monoclinic system,space group P2₁/n with a= 1.339 58（8） nm ,b=1.482 62（9） nm,c=1.713 53（14） nm,β=111.450（3）°,V=3.167 5（4） nm³,Z=2,R₁=0.050 0,wR₂=0.143 4. Complex 2 crystallizes in the monoclinic system,space group P2₁/n with a=11.698 8（7） nm,b=2.407 94（11） nm,c=1.313 20（10） nm,β=91.635（2）°,V=3.697 8（4） nm³,Z=2,R₁=0.039 7,wR₂=0.100 8. The X-ray crystallographic study shows that the crystals are constructed by electrostatic forces and hydrogen bond interactions among decavanadate anions,protonated ABOB cations and lattice water molecules. The polyanions,cations and water molecules arrayed in a good order to form 2D layered arrangements along the c axis in complex 1. The antibacterial trial shows that the two complexes show an good antibacterial activity against Staphylococcus aureus,Staphylococcus epidermis,MRSA and MRSE.

Key words: Decavanadate, Moroxydine(ABOB), Self-assembly, Synthesis, Antibacterial activity

中图分类号:

O614

TrendMD:

刘术侠, 翟宏菊, 彭军, 李德慧, 戴知旻, 王恩波, 胡宁海, 贾恒庆. 吗啉胍同多十钒酸盐的自组装合成、结构表征及抗菌活性. 高等学校化学学报, 2004, 25(6): 997.

LIU Shu-Xia, ZHAI Hong-Ju, PENG Jun, LI De-Hui, DAI Zhi-Min, WANG En-Bo, HU Ning-Hai, JIA Heng-Qing. Self-assembly Synthesis,Structure Characterization and Antibacterial Activity of Complexes （ABOB）₄[H₂V₁₀O₂₈]·9H₂O and （ABOB）₆[V₁₀O₂₈] ·4H₂O（ABOB=Moroxydine）. Chem. J. Chinese Universities, 2004, 25(6): 997.

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