高等学校化学学报

高等学校化学学报 ›› 1997, Vol. 18 ›› Issue (3): 395.

• 论文 • 上一篇    下一篇

一类新型酰基脲化合物的设计、合成及生物活性

杨新玲1, 王道全1, 陈馥衡1, 凌云1, 张钟宁2, 尚稚珍3   

  1. 1. 中国农业大学应用化学系, 北京, 100094;
    2. 中国科学院动物研究所;
    3. 南开大学元素有机化学研究所
  • 收稿日期:1996-05-08 出版日期:1997-03-24 发布日期:1997-03-24
  • 通讯作者: 杨新玲, 女, 28岁, 博士, 讲师.
  • 作者简介:杨新玲, 女, 28岁, 博士, 讲师.
  • 基金资助:

    国家教育委员会博士学科点基金;国家自然科学基金

Studies on the Design,Synthesis and Biological Activity of a Novel Type of Acylurea Compound

YANG Xin-Ling1, WANG Dao-Quan1, CHEN Fu-Heng1, LING Yun1, ZHANG Zhong-Ning2, SHANG Zhi-Zhen3   

  1. 1. Department of Applied Chemistry, China Agricultural University, Beijing, 100094;
    2. Animal Institute, Acadenic Sinica, Beijing;
    3. Institute of Elentento-Organic Chemistry, Nattkai Univrrsity, Tianjin
  • Received:1996-05-08 Online:1997-03-24 Published:1997-03-24

PDF (PC)

被引次数

20

摘要： 设计并合成了21个新型含呋喃环的双酰基脲化合物,经IR、1HNMR、MS和元素分析确证其结构.初步生物活性测定结果表明,该类化合物具有几丁质抑制活性.

关键词: 双酰基脲, 设计, 合成, 生物活性

Abstract: In order to find new insectlcldes possessing a high activity and excellent selectivity, a novel type of diacylurea containing furan has been designed and prepared.Thus, by the nucleophilic addition reaction of 5-substituted futamide and benzoyl isocyanate, 21 compounds of N-benzoyl-N'-[5-substituted furoyl]urea were obtained in 74.5 % ～ 99.5 % yield.Their structures were confirmed by elementary analysis, IR, 1HNMR and MS.The result of preliminary bioassay demonstrates that some of them show chitin-inhibiting activity against mosqito larvae at 10 mg/L.Especially, compounds 1, 15 and 21 exhibited ＞8O%mortality to larval mosquitoes with the same dead symptom as IKI-7899.

Key words: Diacylurea, Design, Synthesis, Biological activity

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