高等学校化学学报

高等学校化学学报 ›› 1996, Vol. 17 ›› Issue (9): 1394.

• 论文 • 上一篇    下一篇

N-(1-氧代-1-磷杂-2,6,7-三氧杂双环[2.2.2]-辛烷-4-羰基)-N'-芳(烷)基硫脲的合成及结构研究

李玉桂, 朱雪峰, 黄芹, 刘军   

  1. 南开大学元素有机化学研究所, 天津, 300071
  • 收稿日期:1995-09-11 出版日期:1996-09-24 发布日期:1996-09-24
  • 通讯作者: 李玉桂,女,61岁,教授.
  • 作者简介:李玉桂,女,61岁,教授.
  • 基金资助:

    国家自然科学基金

Studies on the Synthesis and Structure of N-(1-Oxo-1-phospha-2,6,7-trioxabicyclo[2.2.2]octane-4-carbonyl)-N'-aryl(alkyl)thioureas

LI Yu-Gui, ZHU Xue-Feng, HUANG Qin, LIU Jun   

  1. Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 1300071
  • Received:1995-09-11 Online:1996-09-24 Published:1996-09-24

PDF (PC)

摘要： 首次合成了酰基异硫氰酸酯4,并将其与各种芳胺、脂肪胺和肼衍生物加成,得到了22种未见文献报道的含双环笼状磷酸酯结构的酰基硫脲化合物(5a-5x),4与丁胺反应未得到预期的加成产物,而得到相应的取代产物6,研究了5的结构。

关键词: 双环笼状磷酸酯, 异硫氰酸酯, 胺, 硫脲, 加成反应

Abstract: Twenty-two carbonyl thioureas derivatives──N-(1-oxo-1-phospha-2,6,7-trioxabicyclo[2.2.2]octane- 4- carbonyl)- N'- aryl(alkyl)thioureas 5a─5x were synthesized by the addition reaction of 1-oxo-4-carbonyl isothiocyanate-2, 6, 7-trioxa-1-phosphabicyclo[2.2 .2]octane 4 with various amines.The IRand 1H NMRspectra of 5 show that most of them exist in the keto-thioketo form and only a few of them have keto-thioenol tautomer.IRand 1H NMRdata also indicate that compounds 5 have intramolecular hydrogen bond.The structures of 5 were also confirmed by elementary analysis and MS.The biological activities of 5 and the crystal structure of compound 5q are being tested.

Key words: Caged bicyclic phosphates, Isothiocyanate, Amines, Thioureas, Addition

TrendMD: