高等学校化学学报

高等学校化学学报 ›› 1996, Vol. 17 ›› Issue (8): 1235.

• 论文 • 上一篇    下一篇

几类4-取代苄基-2,6-哌嗪二酮的合成

覃兆海1, 陈馥衡1, 谢毓元2   

  1. 1. 北京农业大学应用化学系, 北京 100094;
    2. 中国科学院上海药物研究所
  • 收稿日期:1995-08-12 出版日期:1996-08-24 发布日期:1996-08-24
  • 通讯作者: 覃兆海,男,32岁,博士,副教授.
  • 作者简介:覃兆海,男,32岁,博士,副教授.

Synthesis of Some 4-(Un) Substituted Benzyl Piperazine-2,6-diones

QIN Zhao-Hai1, CHEN Fu-Heng1, XIE Yu-Yuan2   

  1. 1. Institute of Applied Chemistry, Beijing Agricultural University, Beijing 100094;
    2. Shanghai Institute of Materia Medica, Medica, Academia Sinica
  • Received:1995-08-12 Online:1996-08-24 Published:1996-08-24

PDF (PC)

摘要： 介绍了4类具有络合性质或潜在的络合性质的4-取代苄基-2,6-哌嗪二酮化合物的合法。所合成的化合物中有些表现出明显的体外抑制白血细胞P388生长的活性。

关键词: 2, 6-哌嗪二酮, 合成, 抗肿瘤

Abstract: The development of several methods for the synthesis of four classes of 1,4-disubstituted piperazine-2,6-diones which have chelating effects or latent chelating effects is described.Some of them are proved to be considerably effective against P388 cells in vitro.

Key words: Piperazine-2,6-dione, Synthesis, Anticancer

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