高等学校化学学报

高等学校化学学报 ›› 1995, Vol. 16 ›› Issue (7): 1064.

• 研究快报 • 上一篇    下一篇

RuNi双核配合物识别DNA的分子机理研究

卜显和1, 朱树梅2, 杨铭2, 王夔2   

  1. 1. 南开大学化学系, 天津, 300071;
    2. 北京医科大学天然及仿生药物国家重点实验室
  • 收稿日期:1995-01-07 修回日期:1995-04-03 出版日期:1995-07-24 发布日期:1995-07-24
  • 通讯作者: 卜显和,男,30岁,博士,副教授.
  • 作者简介:卜显和,男,30岁,博士,副教授.
  • 基金资助:

    国家自然科学基金;国家教委优秀归国年轻教师基金;北京医科大学天然及仿生药物国家重点实验室资助课题

Molecular Mechanisms of DNA Recognition by RuNi Heterobinuclear Complexes

BU Xian-He1, ZHU Shu-Mei2, YANG Ming2, WANG Kui2   

  1. 1. Department of Chemistry, Nankai University, Tianjin, 300071;
    2. State Key Lab. of Natural and Biomimetic Drugs, Beijing Med. Univ., Beijing
  • Received:1995-01-07 Revised:1995-04-03 Online:1995-07-24 Published:1995-07-24

PDF (PC)

被引次数

22

摘要： RuNi异金属双核配合物Ru(phen)2(phen-cyclam-Ni)4+(1)(phen=1,10-邻菲咯啉;cyclam=1,4,8,11-四氮杂环十四烷)和Ru(bpy)2(bpy-cyclam-Ni)4+"(2)(bpy=2,2'-联吡啶)具有多种重要的性质和功能;为了阐明它们在体外抗艾滋病病毒(HIV-1)活性方面的分子机理,我们用多种手段研究了这些化合物与DNA的相互作用。

关键词: RuNi异金属双核配合物, DNA, 识别

Abstract: The interactions of a new class of intelligent RuNi heterobinuclear complexes, which have been found to be potent inhibitors of HIV-Ireplication, with DNA having been studied. The complexes bind to DNA by intercalation based on increment in viscosity on titration with CT-DNA. The binding strength was further evaluated by spectroscopic measurements. Gel electrophoresis reveals the conversion of supercooled pBR322 DNA to the nicked form and linear form, which is induced by the Ru part of the complexes.

Key words: RuNi heterobinuclear complex, DNA, Recognition

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