高等学校化学学报 ›› 1993, Vol. 14 ›› Issue (1): 141.

• 研究简报 • 上一篇    下一篇

谷胱甘肽过氧化物酶模拟物的合成及其催化机理研究

马万超, 罗贵民, 王宗睦, 黄仲立, 杨同书   

  1. 吉林大学酶工程实验室, 长春 130023
  • 收稿日期:1992-01-06 修回日期:1992-05-10 出版日期:1993-01-24 发布日期:1993-01-24
  • 通讯作者: 罗贵民

Studies on Synthesis of Glutathione Peroxidase Mimics and Its Catalytic Mechanism

MA Wan-Chao, LUO Gui-Min, WANG Zong-Mu, HUANG Zhong-Li, YANG Tong-Shu   

  1. Laboratory of Enzyme Engineering, Jilin University, Changehum, 130023
  • Received:1992-01-06 Revised:1992-05-10 Online:1993-01-24 Published:1993-01-24

关键词: 谷胱甘肽过氧化物酶, 模拟物, 合成, 催化机理

Abstract: Four selenium-containing compounds were synthesized on the basis of the active site structure of glutathione peroxidase.These compounds indicated a higher activity of glutathione peroxidase than PZ51, which is known as the best mimic compound.Anew catalytic mechanism was proposed based on the chemistry and activity of these synthesized mimics.

Key words: Glutathione peroxidase, Mimics, Synthesis, Catalytic mechanism

TrendMD: