高等学校化学学报 ›› 1991, Vol. 12 ›› Issue (9): 1207.

• 论文 • 上一篇    下一篇

氨基酸合成方法研究(Ⅷ)--N-乙氧羰基亚甲基苯甲亚氨酸乙酯与芳醛的缩合反应

戎娅菁, 施耀曾, 陆婉芳, 胡宏纹   

  1. 南京大学化学系, 南京, 210008
  • 收稿日期:1990-07-24 出版日期:1991-09-24 发布日期:1991-09-24
  • 通讯作者: 施耀曾
  • 基金资助:

    国家自然科学基金

Studies on the Synthesis of Amino Acids (Ⅷ)--Condensation of Ethyl N-ethoxycarbonylmethylimidate and Aromatic Aldehydes

Rong Ya-jing, Shi Yao-zeng, Lu Wan-fang, Hu Hong-wen   

  1. Department of Chemistry, Nanjing University, Nanjing, 210008
  • Received:1990-07-24 Online:1991-09-24 Published:1991-09-24

摘要: α-苯甲酰胺基肉桂酸酯类化合物是合成苯丙氨酸及其衍生物的重要前体,对双键进行手性加氢即可得到光学活性氨基酸,对这类化合物的合成大多涉及噁唑酮的水解或β-位官能化氨基酸的β-消除。

关键词: 亚氩酸酯, 缩合反应, 氨基酸

Abstract: The condensation of ethyl N-ethoxycarbonylmethylimidate (1) and aromatic aldehydes (2) in the presence of sodium ethoxide is described. The products, Z/E-a-benzamidocimmamates, are important intermediates in the synthesis of amino acids.

Key words: Imidate, Condensation, A mino acid

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