Studies of the Synthesis and Antitumor Activity of 5-Fluorouracil Derivatives Containing D-Aminoglucose Residue

Abstract

Abstract: This investigation describes the effect of D-aminoglucose on the antitumor activity of 5-fluorouracil.By choosing α-amino acids as connective group, we have synthesized 4 kinds of 5-fluorouracil derivatives containing D-aminoglucose residue.Their structures were confirmed by ¹H NMR,IR, UVspectra and elemental analysis.The data of activity against the isolated ehrlich ascites tumor cells in vitro has been evaluated.The preliminary results show that these compounds all exhibit much better antitumor activity than 5-fluorouracil it-self does.

Key words: D-Aminoglucose, 5-Fluorouracil, Antitumor, α-Amino acid, Chitin

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LUO Xuan-Gan, ZHUO Ren-Xi, LI Man-Qing . Studies of the Synthesis and Antitumor Activity of 5-Fluorouracil Derivatives Containing D-Aminoglucose Residue[J]. Chem. J. Chinese Universities, 1996, 17(9): 1416.

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Studies of the Synthesis and Antitumor Activity of 5-Fluorouracil Derivatives Containing D-Aminoglucose Residue

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