Method Measuring of Hydrophobic Parameter of Organic Compounds via a Novel Liposome Capillary Electrophoresis

Chem. J. Chinese Universities

Previous Articles Next Articles

Method Measuring of Hydrophobic Parameter of Organic Compounds via a Novel Liposome Capillary Electrophoresis

DONG Zhi-Qiang¹, XIA Zhi-Ning^1,2*, JIANG Xue-Mei²

1. Department of Pharmaceutics, Institute of Chemistry and Chemical Engineering,
2. College of Bioengineering, Chongqing University, Chongqing 400030, China

Received:2006-11-09 Revised:1900-01-01 Online:2007-07-10 Published:2007-07-10
Contact: XIA Zhi-Ning

Abstract

Abstract:

Liposome capillary electrophoresis(LCE) provides a novel and facile approach for determining hydrophobic parameters(lgP) of organic compounds. In order to avoid the error of the migration time of liposome phase(t_l) on determination, a novel technique was developed in this paper, in which the tl was obtained via non-linearity fitting with lgP values from literatures and migration time(t_m) of a series of standard compounds. lgP values of the six benzene derivatives determined by this LCE method were compared with literature values and the ones obtained by directly determined t_l and MEEKC. The average error between lgP values determined by two LCE methods was 0.07 logarithm units. The LCE method was simple and rapid, which can provide a new way to determine lgP of organic compounds.

Key words: Liposome, Capillary electrophoresis, Hydrophobic parameter, Iteration

CLC Number:

O657

TrendMD:

DONG Zhi-Qiang¹, XIA Zhi-Ning^1,2*, JIANG Xue-Mei². Method Measuring of Hydrophobic Parameter of Organic Compounds via a Novel Liposome Capillary Electrophoresis[J]. Chem. J. Chinese Universities, doi: .

[1]	QIN Gaizhao, TANG Minghua, LAI Yalin, YUAN Liming. Chiral Metal-organic Cage MOC-PA as a Chiral Stationary Phase for Capillary Electrophoresis [J]. Chem. J. Chinese Universities, 2022, 43(11): 20220417.
[2]	WANG Tingting, LEI Yuhan, LIN Yujuan, HUANG Jialing, LIU Cuie, ZHENG Fengying, LI Shunxing. Preparation of Liposome-terminated CsPbX₃(X=Cl,Br,I) Nanocrystals and Applications in Light-emitting Diode Devices [J]. Chem. J. Chinese Universities, 2020, 41(8): 1896.
[3]	HU Xueyi, CHEN Miaomiao, FANG Yun, FENG Ruiqin, HAN Huihui. Investigation on Pseudo-polyanions of Cationic Cellulose-Sodium Dodecylbenzenesulfonate^† [J]. Chem. J. Chinese Universities, 2019, 40(7): 1464.
[4]	ZHAO Wencai, HAN Lili, PENG Yingjun, WANG Xiaojing, LIU Shengyu, LI Pengfei, HUANG Yibing, CHEN Yuxin. Effect of Basic Amino Acids on the Biological Activity of Helical Antimicrobial Peptide^† [J]. Chem. J. Chinese Universities, 2018, 39(4): 681.
[5]	WEI Yanshan, WEI Bangzhi, HUANG Aimin, MA Lin. Membrane Structure Alteration of DOPC Liposome Induced by Interaction with Gene Carrier Polyethyleneimine^† [J]. Chem. J. Chinese Universities, 2017, 38(12): 2271.
[6]	HUO Yilin, SHI Ying, WANG Qinyue, LI Luoyuan, YU Longjiang, WANG Peng, ZHANG Jianping, WANG Zhengyu. Spectroscopic Properties of LH2 from Thermochromatium tepidum in Liposome and Detergent Micelles^† [J]. Chem. J. Chinese Universities, 2016, 37(9): 1678.
[7]	ZOU Haimin, ZHOU Chen, SUN Chengjun, LI Yongxin, YANG Xiaosong, WEN Jun, ZENG Hongyan. Simultaneous Determination of 7 Components in Functional Food for Anti-hangover and Hepatoprotection by Capillary Electrophoresis^† [J]. Chem. J. Chinese Universities, 2016, 37(7): 1276.
[8]	HU Can, CHEN Yi. Dissolution/diffusion-based Injection for Fast Separation of Epinephrine and Norepinephrine by Short Capillary Electrophoresis^† [J]. Chem. J. Chinese Universities, 2015, 36(9): 1681.
[9]	XIONG Wen, QUAN Chunshan, WANG Lina, ZHANG Xuning, ZHAO Jing, ZHENG Wei, FAN Shengdi. Effect of Different Charged Liposomes on Transmembrane Incorporation Efficiency of the Staphylococcus Aureus Receptor Histidine Kinase AgrC^† [J]. Chem. J. Chinese Universities, 2014, 35(9): 1901.
[10]	WEI Yu, CHEN Yufu, ZHOU Qiang, YUAN Qiuyue, TAN Fengyu, XIE Tianyao. Enantioseparation of Underivatized D,L-Serine in Biological Matrices by Capillary Electrophoresis with Contactless Conductivity Detection^† [J]. Chem. J. Chinese Universities, 2014, 35(7): 1409.
[11]	YANG Jiao-Mei, REN Jie, LIU Hui-Qing, WANG Yong-Le, XU Zhong-Qi. Separation and Detection of Neurotransmitter-related Substances in Urine Sample by Capillary Electrophoresis [J]. Chem. J. Chinese Universities, 2013, 34(12): 2699.
[12]	ZHANG Xiao-Fei, SUN Run-Guang, HAO Chang-Chun, YANG Qian, ZHAO Yan. Morphology and Mechanics Character of PVP-Modified Liposome [J]. Chem. J. Chinese Universities, 2012, 33(08): 1751.
[13]	QIU Chang-Gui, WANG Xiao-Yu, GUO Zhen-Peng, SONG Li-Juan, CHEN Yi. Chiral Ligand-exchange Capillary Electrophoretic Assay of L-Dopa Tablets Using a Non-analyte Chiral Ligand [J]. Chem. J. Chinese Universities, 2012, 33(03): 470.
[14]	LI Guang-Hui, SHEN Hai-Xing, QIAN Jun, SI Zhan, ZHU Jian-Hua*. 125I-AIBZM Nanoliposomes Targeting Brain as Imaging Agents [J]. Chem. J. Chinese Universities, 2011, 32(6): 1295.
[15]	LI Yu-Rong, CHEN Chang-Bao, ZHOU Jie*. Separation of DNA Fragments with a Broad Range of Molecular Weight by Capillary Electrophoresis with Sieving Matrix of Poly(ethylene oxide) [J]. Chem. J. Chinese Universities, 2011, 32(4): 844.

Method Measuring of Hydrophobic Parameter of Organic Compounds via a Novel Liposome Capillary Electrophoresis

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments