Synthesis and Antitumor Activities of Spin Labeled Derivatives of Daunorubicin and Doxorubicin

Chem. J. Chinese Universities ›› 2000, Vol. 21 ›› Issue (6): 884.

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Synthesis and Antitumor Activities of Spin Labeled Derivatives of Daunorubicin and Doxorubicin

MA Cheng, WANG Yan-Guang, CHEN Yao-Zu

Department of Chemistry, Zhejiang University, Hangzhou 310027, China

Received:1999-07-19 Online:2000-06-24 Published:2000-06-24

Abstract

Abstract: Five new spin-labeled derivatives of daunorubicin and doxorubicin(5_9) were synthesized and their structures were identified by IR, MSand ESRas well as elementary analysis. All new compounds were evaluated for their antitumor activities against mouse leukemia P388, B16, human stomach carcinoma SGC-7901 and human liver cancer SMMC7721 cells in vitro. The preliminary results showed that compound 9 was as active as the clinically used doxorubicin.

Key words: Antitumor, Nitroxyl, Daunorubicin, Doxorubicin

CLC Number:

R914.5

TrendMD:

MA Cheng, WANG Yan-Guang, CHEN Yao-Zu . Synthesis and Antitumor Activities of Spin Labeled Derivatives of Daunorubicin and Doxorubicin[J]. Chem. J. Chinese Universities, 2000, 21(6): 884.

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Synthesis and Antitumor Activities of Spin Labeled Derivatives of Daunorubicin and Doxorubicin

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