Chem. J. Chinese Universities ›› 2016, Vol. 37 ›› Issue (5): 860.doi: 10.7503/cjcu20150938
• Analytical Chemistry • Previous Articles Next Articles
ZHANG Yan, ZHENG Jing, WANG Juan, GUO Mandong*()
Received:
2015-12-17
Online:
2016-05-10
Published:
2016-04-12
Contact:
GUO Mandong
E-mail:guomd@dns.sxnu.edu.cn
Supported by:
CLC Number:
TrendMD:
ZHANG Yan, ZHENG Jing, WANG Juan, GUO Mandong. Preparation and Properties of Doxorubicin Hydrochloride Sensor Based on Molecularly Imprinted Polymer†[J]. Chem. J. Chinese Universities, 2016, 37(5): 860.
Fig.2 CV curves for the electrochemical polymerization of EDOT in the absence(A) and presence(B) of DOX in PBS Scan rate: 50 mV/s; cycling number: (A) 10; (B) 7.
Fig.3 CV curves of the electrodes in 0.1 mol/L KCl containing 5 mmol/L K3[Fe(CN)6](A) and electrochemical impedance spectroscopy of the electrodes(B)(A) a. Au/CME; b. PEDOT/Au/CME; c. AuNPs-CS/PEDOT/Au/CME; d. DOX-MIPs/AuNPs-CS/PEDOT/Au/CME; e. MIPs/AuNPs-CS/PEDOT/Au/CME; f. NMIPs/AuNPs-CS/PEDOT/Au/CME. (B) ■ Au/CME;▼ DOX-MIPs/AuNPs-CS/PEDOT/Au/CME; ● PEDOT/Au/CME; ▲ AuNPs-CS/PEDOT/Au/CME.
Fig.6 DPV curves of MIP/AuNPs-CS/PEDOT/Au/CME after adsorption in different concentrations of DOX(A) and linear relationship of current peak difference vs. DOX concentration on MIP/AuNPs-CS/PEDOT/Au/CME(B)
Method | Linear range/(mol·L-1) | 108 Detection limit | Ref. |
---|---|---|---|
High performance liquid chromategraphy | 1.7×10-7—1.7×10-5 | 17.0 | [1] |
Capillary electrophoresis | 1.0×10-6—1.0×10-5 | 29.0 | [2] |
Fluorescence spectroscopy | 7.8×10-8—5.2×10-6 | 2.3 | [3] |
The proposed method | 6.9×10-7—4.3×10-6 | 5.0 | [4] |
Flow injection chemilumin-escence method-escence method | 4.0×10-7—1.0×10-6 | 6.5 | This work |
Table 1 Comparison of detection results of DOX by this method and literature methods
Method | Linear range/(mol·L-1) | 108 Detection limit | Ref. |
---|---|---|---|
High performance liquid chromategraphy | 1.7×10-7—1.7×10-5 | 17.0 | [1] |
Capillary electrophoresis | 1.0×10-6—1.0×10-5 | 29.0 | [2] |
Fluorescence spectroscopy | 7.8×10-8—5.2×10-6 | 2.3 | [3] |
The proposed method | 6.9×10-7—4.3×10-6 | 5.0 | [4] |
Flow injection chemilumin-escence method-escence method | 4.0×10-7—1.0×10-6 | 6.5 | This work |
106 Concentration added/ (mol·L-1) | Current response/μA | 106 Concentration detected mol/L | Recovery(%) | RSD(%) | ||
---|---|---|---|---|---|---|
First | Second | Third | ||||
1 | -4.96 | -4.80 | -4.86 | 9.4 | 96.0 | 1.66 |
3 | -7.32 | -7.23 | -7.15 | 3.2 | 106.7 | 1.39 |
5 | -8.95 | -8.80 | -8.83 | 4.86 | 97.2 | 0.90 |
7 | -11.04 | -10.90 | -10.86 | 7.13 | 101.9 | 0.86 |
Table 2 Determination result of DOX in blood serum samples
106 Concentration added/ (mol·L-1) | Current response/μA | 106 Concentration detected mol/L | Recovery(%) | RSD(%) | ||
---|---|---|---|---|---|---|
First | Second | Third | ||||
1 | -4.96 | -4.80 | -4.86 | 9.4 | 96.0 | 1.66 |
3 | -7.32 | -7.23 | -7.15 | 3.2 | 106.7 | 1.39 |
5 | -8.95 | -8.80 | -8.83 | 4.86 | 97.2 | 0.90 |
7 | -11.04 | -10.90 | -10.86 | 7.13 | 101.9 | 0.86 |
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