Investigations on the Adsorbents for Uremic Middle Molecular Toxins(Ⅲ)——Crosslinked Chitosan Bases Modified by Acidic Amino Acids

Abstract

Abstract: Adsorbents for uremic middle molecular toxins were prepared by grafting acidic amino acids on chitosan bases. Six peptides with middle molecular weight from 500 to 5 000 were selected as the model uremic toxins accumulated in patient′s sera. The results show that these adsorbents have certain adsorption ability on the model peptides and middle molecules in patient′s at serum.

Key words: Hemoperfusion, Middle molecular substances, Chitosan, Adsorbent

CLC Number:

R318.08

TrendMD:

WANG Hong, ZHANG Ming-Ming, YANG Mei, L� Jian, YUAN Zhi, HE Bing-Lin, LIU Bin, ZHAO Cheng-Mei, SHEN Bin . Investigations on the Adsorbents for Uremic Middle Molecular Toxins(Ⅲ)——Crosslinked Chitosan Bases Modified by Acidic Amino Acids[J]. Chem. J. Chinese Universities, 2004, 25(3): 474.

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