Hemocompatibility of Carboxylic Graphene Oxide

Chem. J. Chinese Universities ›› 2010, Vol. 31 ›› Issue (12): 2354.

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Hemocompatibility of Carboxylic Graphene Oxide

XU Dong^1,2, ZHOU NingLin^1,2,3*, SHEN Jian^1,2,3

1. Jiangsu Engineering Research Center for Biomedical Function Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097, China
2. Jiangsu Key Laboratory of Biofunctional Materials, Nanjing Normal University, Nanjing 210097, China;
3. Jiangsu Technological Research Center for Interfacial Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China

Received:2010-03-01 Revised:2010-06-11 Online:2010-12-10 Published:2010-12-06
Contact: ZHOU Ning-Lin E-mail:zhouninglin@njnu.edu.cn
Supported by:
Province Natural Science Foundation of Jiangsu;National Natural Science Foundation of China

Abstract

Abstract: Functionalization of Graphene oxide is important for technological applications since it allows integrating into different environments such as biological fluids, polymer matrices, silicon surface and others. Graphene oxide was made through the ultrasonic separation of graphite oxide, and then it was modified with functional group by chloroacetic acid, and finally, the graphene oxide modified with carboxyl groups was prepared. Compared with graphene oxide, the FTIR of GeneO-COOH showed a weaker -OH peak, a stronger -COOH peak, and a bigger peak width. FTIR showed partial epoxy and hydroxyl were activated into carboxyl. On TG spectrum, the main weight loss of GeneO-COOH showed condensation of -COOH groups in the form of a loss of structural water. The curve which reflected the kinetic profiles of recalcification time was changed from steep to gentle along with the increases of the consistency of GeneO-COOH. The recalcification time of GeneO-COOH was prolonged by 11 min at 1.25μg/mL, and the value of OD reduced by 8.14%. The hematolysis ratio was less than 5 % within the range of 0.5~100μg/mL. The anti-clotting property of GeneO-COOH was better than that of GeneO at the same low concentration. The improvement was mainly made by carboxyl group with a negative charge and direct complexation between carboxyl group and clotting factor. Hence, it may be conclude that GeneO-COOH may be suitable as biomaterials in the field of medical.

Key words: arboxyl group, surface modification, graphene oxide, hemocompatibility

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Hemocompatibility of Carboxylic Graphene Oxide

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