Chemical Journal of Chinese Universities ›› 2020, Vol. 41 ›› Issue (6): 1151-1162.doi: 10.7503/cjcu20200067

• Review • Previous Articles     Next Articles

Construction of Controllable Lipid-DNA Complex for Study in Membrane Biology

ZHANG Luhao1,2,CAO Shuting1,2,LIU Jiangbo3,ZUO Xiaolei3,WANG Lihua1,4,FAN Chunhai1,3,*(),LI Jiang1,4,*()   

  1. 1. CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
    2. University of Chinese Academy of Sciences, Beijing 100049, China
    3. Institute of Molecular Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China
    4. Shanghai Synchrotron Radiation Facility, Zhangjiang Laboratory, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201204, China
  • Received:2020-02-10 Online:2020-06-10 Published:2020-03-23
  • Contact: Chunhai FAN,Jiang LI;
  • Supported by:
    † National Natural Science Foundation of China(21775157);National Natural Science Foundation of China(21834007);National Natural Science Foundation of China(21675167)


This review briefly summarized recent progress of lipid-DNA complexes, including their design, construction, and unique features. We highlighted their applications on living cell membranes, including dynamic membrane analysis, nanopores, live cell organization and interaction regulation, and drug delivery. We also summarized challenges in this field. We suggest that by using these lipid-DNA conjugates, cell membrane functions at the molecular level can be better understood and manipulated, which may facilitate the development of cell imaging, theranostics, construction of nanodevices and protocells.

Key words: Lipid-DNA complex, Membrane anchoring, Membrane biology

CLC Number: