FTIR Spectrum Comparisons Among the Breast tissues: the Normal Tissues,  Hyperplasia,  Fibroadenoma and Cancer

Chem. J. Chinese Universities ›› 2011, Vol. 32 ›› Issue (2): 246.

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FTIR Spectrum Comparisons Among the Breast tissues: the Normal Tissues, Hyperplasia, Fibroadenoma and Cancer

ZHAO Jin¹, LIU Ya-Qi¹, XU Yi-Zhuang², ZHANG Yuan-Fu², WU Jin-Guang², HOU Kuan-Yong¹, ZHAO Hong-Mei¹, LEI Yu-Tao¹, ZHOU Xiao-Si¹, XU Zhi¹, LING Xiao-Feng^1*

1. Department of General Surgery, Peking University Third Hospital, Beijing 100191, China;
2. College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China

Received:2010-09-25 Revised:2010-12-03 Online:2010-02-10 Published:2011-02-23
Contact: LING Xiao-Feng E-mail:xiaofengling@bjmu.edu.cn
Supported by:
北京市自然科学基金项目(批准号: 2072020)资助.

Abstract

Abstract: Abstract: In the present study , Fourier Transform Infrared Spectroscopy (FTIR) spectra of 77 freshly removed breast tissues were collected by spectrometer equipped with an ATR (Attenuated Total Reflectance) probe. These breast samples included 18 normal tissues, 13 hyperplasia, 21 fibroadenoma and 25 cancer. For each FTIR spectrum,. the Peak positions (P.), relative intensity ratios (I.) and full width at half maximum (F.) of the 13 bands were measured. The differences among the four types of breast tissue were compared by ANOVA(Analysis of Variance) and Rank-sum test. These FTIR parameters were significantly different (P<0.05) among the four types . In conclusion, FTIR spectroscopy could illustrate the significant differences among the normal, hyperplasia, fibroadenoma and breast cancer tissues. It can present with a novel approach of detecting cancer in situ and in vivo intraoperatively.

Key words: FTIR, breast cancer, fibroadenoma, hyperplasia of mammary glands

CLC Number:

O657.3

TrendMD:

ZHAO Jin, LIU Ya-Qi, XU Yi-Zhuang, ZHANG Yuan-Fu, WU Jin-Guang, HOU Kuan-Yong, ZHAO Hong-Mei, LEI Yu-Tao, ZHOU Xiao-Si, XU Zhi, LING Xiao-Feng*. FTIR Spectrum Comparisons Among the Breast tissues: the Normal Tissues, Hyperplasia, Fibroadenoma and Cancer[J]. Chem. J. Chinese Universities, 2011, 32(2): 246.

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FTIR Spectrum Comparisons Among the Breast tissues: the Normal Tissues, Hyperplasia, Fibroadenoma and Cancer

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