Study on Fresh Breast Tissues by Near-infrared Raman Spectroscopy

doi:10.7503/cjcu20130131

Abstract

Abstract:

A portable Raman spectrometer was used for distinguishing the characteristics of normal, malignant and benign fresh breast biopsy samples. Based on spectral profiles, the presence of lipids(1230, 1268, 1301, 1440, 1743 cm^-1) is indicated in normal tissue. And proteins(amide Ⅰ, and amide Ⅲ, 1246, 1271, 1315, 1364 cm^-1) are found in benign and malignant tissues. Between benign and malignant, nucleic acids(1340 cm^-1) are found to be good discrimination parameters. In the process of data analysis, the model was set up by Gaussian Process with the intensity of the feature, and obtained the specificity(0.94), sensibility(0.95) and Matthews correlation coefficient(MCC, 0.86). This study shows the significance in diagnosing breast disease, and contributes fundamentally to further application on clinic.

Key words: Raman spectroscopy, Breast cancer, Guassian process

CLC Number:

O657

TrendMD:

HU Cheng-Xu, ZHENG Chao, ZHANG Hai-Peng, BI Li-Rong, XU Shu-Ping, FAN Zhi-Min, HAN Bing, XU Wei-Qing. Study on Fresh Breast Tissues by Near-infrared Raman Spectroscopy[J]. Chem. J. Chinese Universities, 2013, 34(12): 2721.

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