Preparation and Property of Chitosan/Sodium Tripolyphosphate Microcapsules as Drug Carrier

Chem. J. Chinese Universities

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Preparation and Property of Chitosan/Sodium Tripolyphosphate Microcapsules as Drug Carrier

YANG Wen-Jing, WANG Ting, HE Nong-Yue^*

State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China

Received:2008-07-01 Revised:1900-01-01 Online:2009-03-10 Published:2009-03-10
Contact: HE Nong-Yue

Abstract

Abstract: Chitosan/sodium tripolyphosphate(CS/TPP) nano-sized microcapsules were prepared with ionic gelation of CS with TPP. The obtained CS nano-sized microcapsules were characterized with the infrared spectra(IR), scanning electron microscope(SEM) and the particle size analyzer. The model protein, bovine serum albumin(BSA) as a model drug, was encapsulated into the CS/TPP nano-sized microcapsules. Infrared spectrum of CS/TPP nano-sized microcapsules indicated that CS was cross-linked with TPP. The average diameter of the obtained nano-sized microcapsules was around 430 nm, and a homogeneous size distribution and good dispersion were observed. BSA-loading efficiency of CS/TPP nano-sized microcapsules did not increase with the increase in concentration of CS. When mass fraction of CS was 0.25%, the highest BSA-loading efficiency of CS/TPP nano-sized microcapsules reached 79.74%, while BSA continually and smoothly released up to one week.

Key words: Chitosan(CS), Sodium tripolyphosphate(TPP), Drug-releasing

CLC Number:

O636
R318.08

TrendMD:

YANG Wen-Jing, WANG Ting, HE Nong-Yue^*. Preparation and Property of Chitosan/Sodium Tripolyphosphate Microcapsules as Drug Carrier
[J]. Chem. J. Chinese Universities, doi: .

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Preparation and Property of Chitosan/Sodium Tripolyphosphate Microcapsules as Drug Carrier

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