Steady-state and Time-resolved Spectroscopic Studies on the Interaction Between TMPyP4 and Nucleic Acids

Chem. J. Chinese Universities

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Steady-state and Time-resolved Spectroscopic Studies on the Interaction Between TMPyP4 and Nucleic Acids

WANG Xue-Fei^1,2, ZHANG Hui-Juan³, WU Yi-Shi^1,2, WANG Peng², AI Xi-Cheng²*, ZHANG Jian-Ping^1,2

1. Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China;
2. Department of Chemistry, College of Sciences, Renmin University of China, Beijing 100872, China;
3. School of Life Science & Technology, Beijing Institute of Technology, Beijing 100081, China

Received:2006-10-09 Revised:1900-01-01 Online:2007-07-10 Published:2007-07-10
Contact: AI Xi-Cheng

Abstract

Abstract: Steady-state absorption and fluorescence, circular dichroism and picosecond time-resolved fluorescence spectroscopies were used to investigate the interaction between 5,10,15,20-tetrakis(4-N-methylpyridine)porphyrin (TMPyP4) and nucleic acid molecules, i.e. bases (A, G, T, C), deoxynucleosides (dA, dG, dT, dC), deoxynucleotides (dAMP, dGMP, dTMP, dCMP) and oligonucleotides (dA₆, dG₆, dT₆, dC₆). The results show that the interactions between TMPyP4 and the purine species were stronger than that between TMPyP4 and the pyrimidine species. For a certain series of species, such as A, dA, dAMP and dA6, the interaction strength follows the order: base-nucleoside

Key words: Porphyrin, Porphyrin, Nucleic acid, Nucleic acid, Binding constant, Binding constant, Spectroscopy, Spectroscopy

CLC Number:

O641.3

TrendMD:

WANG Xue-Fei^1,2, ZHANG Hui-Juan³, WU Yi-Shi^1,2, WANG Peng², AI Xi-Cheng²*, ZHANG Jian-Ping^1,2. Steady-state and Time-resolved Spectroscopic Studies on the Interaction Between TMPyP4 and Nucleic Acids[J]. Chem. J. Chinese Universities, doi: .

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Steady-state and Time-resolved Spectroscopic Studies on the Interaction Between TMPyP4 and Nucleic Acids

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