Synthesis and Characterization of PLGA-(ASP-DIOL)-x-PLGAs Copolymer Containing Pendant Amino Groups with Different Densities

Abstract

Abstract: A series of poly(ASP-Diol)-xs were prepared by polycondensation reactions of N-CBz-L-aspartic acid anhydride with diols of different molecular weights including ethylene glycol, triethylene glycol, PEG200 and PEG600, respectively. They were used as the macromonomer initiators respectively to synthesize biodegradable copolymers PLGA-(ASP-Diol)-x-PLGAs containing pendant amino groups with different contents by ring-opening copolymerization of lactide/glycolide(molar ratio 75/25). Their structures were confirmed by ¹HNMR, FTIR, EA, DSC and GPC. The results indicate that the main factor that affects the molecular weights of the prepolymers is not the molecular weights of diols, but the activity of the end hydroxyl groups. With increasing the chain length of the diols, the content of amino groups in the copolymers decreased, and the glass translation temperature(T-g) decreased obviously, therefore, it is considered that the content and distribution of amino groups in the copolymers can be effectively adjusted by changing the chain length of the diols.

Key words: N-CBz-L-aspartic acid, Poly(lactic acid), Poly(glycol acid), Polyethylene glycol

CLC Number:

O631

TrendMD:

ZHAO Jie, QUAN Da-Ping, LIAO Kai-Rong, WU Qing . Synthesis and Characterization of PLGA-(ASP-DIOL)-x-PLGAs Copolymer Containing Pendant Amino Groups with Different Densities[J]. Chem. J. Chinese Universities, 2005, 26(8): 1565.

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Synthesis and Characterization of PLGA-(ASP-DIOL)-x-PLGAs Copolymer Containing Pendant Amino Groups with Different Densities

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