Studies on Ionic Organotin Compounds(Ⅱ)──The Reaction of Trialkyltin Chloride and Triphenyltin Hydroxide withMercaptoacetic Acid in the Presence of Organic Bases

Abstract

Abstract: The study of ionic tin compounds is current attention owing to their diversified molecular structure and wide range of application. Three kinds of ionic organotin compounds were obtained by the reaction of trialkyltin chloride and triphenyltin hydroxide with mercaptoacetic acid in the presence of organic bases. When Ph 3SnCl was treated with HSCH₂COOH, a novel complex [Ph₂ClSn (μ²-SCH₂COO) ][R₃NH] was formed with the cleavage of Ph—Sn and the dephenylation mechanism was proposed and approved by Ph 3SnOH treated with HSCH₂COOH. All of the products were characterized by elemental analysis and ¹H, ¹³C, ¹¹⁹Sn NMR. Antitumor activities of some compounds were tested for Bel-7402 and KB. The results show that the activities of compound B are better than compound A.

Key words: Ionic organotin compound, Reaction mechanism, Organic base

CLC Number:

O621.3

TrendMD:

SUN Li-Juan, SONG Xue-Qing, CHEN Jian-Xin, ZHONG Gui-Yun, XIE Qing-Lan. Studies on Ionic Organotin Compounds(Ⅱ)──The Reaction of Trialkyltin Chloride and Triphenyltin Hydroxide withMercaptoacetic Acid in the Presence of Organic Bases[J]. Chem. J. Chinese Universities, 2004, 25(4): 646.

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Studies on Ionic Organotin Compounds(Ⅱ)──The Reaction of Trialkyltin Chloride and Triphenyltin Hydroxide withMercaptoacetic Acid in the Presence of Organic Bases

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