Preparation and Sustained Release of a New Water-soluble Drug Carrier System Captopril/Si-MCM-41

Abstract

Abstract: Water-soluble anti-hypertension drug Captopril was incorporated in Si-MCM-41 channel by using impregnation wetness method, the mass fraction of drug[m(drug)/m(Si-MCM-41)] was 33.99%. Captopril/Si-MCM-41 assembly was characterized by XRD, IR, UV-visible technique. The sustained release profile was observed by soaking the assembly in vitro simulated stomach fluid. The results suggest that a Captopril/Si-MCM-41 sustained release system was obtained.

Key words: Mesoporous, Si-MCM-41, Captopril, Assembly, Sustained release

CLC Number:

O614

TrendMD:

QU Feng-Yu, ZHU Guang-Shan, HUANG Shi-Ying, LI Shou-Gui, QIU Shi-Lun . Preparation and Sustained Release of a New Water-soluble Drug Carrier System Captopril/Si-MCM-41[J]. Chem. J. Chinese Universities, 2004, 25(12): 2195.

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Preparation and Sustained Release of a New Water-soluble Drug Carrier System Captopril/Si-MCM-41

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